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S. Kitano, N. Endo, M. Shoji, K. Haruyama, S. Kato; Effect of Bromfenac Sodium Ophthalmic Solution on Preventing Cystoids Macular Edema and Inflammation After Phacoemulsification and Implantation of Intraocular Lens in Diabetic Patients. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3470.
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To compare the effect of bromfenac sodium ophthalmic solution (BF) and a steroidal solution (ST) in the prophylaxis of cystoids macular edema and anterior chamber inflammation after phacoemulsification and intraocular lens and asses maclar thickness changes using optical coherence tomography (OCT).
In this prospective study, 62 eyes of 62 patients were randomized to BF group (n=31) or to ST group (n=31). Minimal foveal thickness (MFT), averaged foveal thickness (AFT) and macular volume (MV) were measured using OCT preoperatively, one day, one week, 2 weeks, 4 weeks, and 6 weeks postoperatively. Best-corrected visual acuity (BCVA), intraocular pressure, and flare in the anterior chamber were recorded at each visit. The same method was used to compare patients with retinopathy in the BF (n=16) and ST (n=11) groups.
In the study involving all subjects, the flare in the anterior chamber was significantly (p=0.007) lower in the BF group at postoperative 2 weeks. Subjects with retinopathy, MFT significantly increased in the ST group at postoperative 2 weeks (p=0.006), 4 weeks (p<0.0001), and 6 weeks (p=0.0001). The flare in anterior chamber were significantly lower in the BF group at 4 weeks (p=0.0009) and 6 weeks (p=0.005) and AFT were significantly lower in the BF group at 4 weeks (p<0.0001) and 6 weeks (p<0.0001). No adverse events were noted in either group.
Bromfenac sodium ophthalmic solution was effective in the prevention of CME following cataract surgery, particularly in patients with nonproliferative diabetic retinopathy.
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