May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Effect of Bromfenac Sodium Ophthalmic Solution on Preventing Cystoids Macular Edema and Inflammation After Phacoemulsification and Implantation of Intraocular Lens in Diabetic Patients
Author Affiliations & Notes
  • S. Kitano
    Ophthalmology/Diabetes Center, Tokyo Womens Medical University, Tokyo, Japan
  • N. Endo
    Ophthalmology/Diabetes Center, Tokyo Womens Medical University, Tokyo, Japan
  • M. Shoji
    Ophthalmology/Diabetes Center, Tokyo Womens Medical University, Tokyo, Japan
  • K. Haruyama
    Ophthalmology/Diabetes Center, Tokyo Womens Medical University, Tokyo, Japan
  • S. Kato
    Ophthalmology, University of Tokyo, School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships  S. Kitano, Senju Pharmaceutical CO., LTD, C; N. Endo, None; M. Shoji, None; K. Haruyama, None; S. Kato, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3470. doi:https://doi.org/
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      S. Kitano, N. Endo, M. Shoji, K. Haruyama, S. Kato; Effect of Bromfenac Sodium Ophthalmic Solution on Preventing Cystoids Macular Edema and Inflammation After Phacoemulsification and Implantation of Intraocular Lens in Diabetic Patients. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3470. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the effect of bromfenac sodium ophthalmic solution (BF) and a steroidal solution (ST) in the prophylaxis of cystoids macular edema and anterior chamber inflammation after phacoemulsification and intraocular lens and asses maclar thickness changes using optical coherence tomography (OCT).

Methods: : In this prospective study, 62 eyes of 62 patients were randomized to BF group (n=31) or to ST group (n=31). Minimal foveal thickness (MFT), averaged foveal thickness (AFT) and macular volume (MV) were measured using OCT preoperatively, one day, one week, 2 weeks, 4 weeks, and 6 weeks postoperatively. Best-corrected visual acuity (BCVA), intraocular pressure, and flare in the anterior chamber were recorded at each visit. The same method was used to compare patients with retinopathy in the BF (n=16) and ST (n=11) groups.

Results: : In the study involving all subjects, the flare in the anterior chamber was significantly (p=0.007) lower in the BF group at postoperative 2 weeks. Subjects with retinopathy, MFT significantly increased in the ST group at postoperative 2 weeks (p=0.006), 4 weeks (p<0.0001), and 6 weeks (p=0.0001). The flare in anterior chamber were significantly lower in the BF group at 4 weeks (p=0.0009) and 6 weeks (p=0.005) and AFT were significantly lower in the BF group at 4 weeks (p<0.0001) and 6 weeks (p<0.0001). No adverse events were noted in either group.

Conclusions: : Bromfenac sodium ophthalmic solution was effective in the prevention of CME following cataract surgery, particularly in patients with nonproliferative diabetic retinopathy.

Clinical Trial: : www.umin.ac.jp/ctr/index/htm UMIN000000711

Keywords: diabetic retinopathy • cataract • inflammation 
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