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W. Einbock, L. Berger, U. Wolf-Schnurrbusch, J. Fleischhauer, S. Wolf; Predictive Factors for Visual Acuity of Patients With Diabetic Macular Edema Interpretated Form the Spectralis HRA+OCT (Heidelberg Engineering). Invest. Ophthalmol. Vis. Sci. 2008;49(13):3473.
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To identify features in high resolution OCT images (Spectralis HRA+OCT, Heidelberg Engeneering, Heidelberg, Germany ) as predictors for favourable visual outcome after anti-VEGF therapy in patients with diabetic macular edema (DME).
Diabetic patients with clinical significant macular edema were included into this study. All patient underwent at baseline a full ophthalmic examination including best-corrected ETDRS visual acuity testing (VA), optical coherence tomography imaging (Spectralis HRA+OCT), and fluorescein angiography (FA). The high resolution OCT images show several bands of high reflectivity in the outer retina. These can be attributed to the external limiting membrane, the inner segment/ outer segment junction (IS/OS), and to the RPE. OCT images recorded in patients with clinical significant diabetic macular edema were analyzed for the presence of the outer limiting membrane and the integrity of the inner segment/ outer segment junction (IS/OS). Patients with intact outer limiting membrane were included into group 1, whereas patients with disturbances in the outer limiting membrane were included into group 2. The visual outcome 4 weeks after intravitreal anti-VEGF (Avastin, Roche or Lucentis, Novartis) was analyzed with respect to the OCT findings.
A total of 20 patients were examined and analyzed. On average the patients with intact reflex from the outer limiting membrane (group 1) experienced a visual gain of 9+/-3 letters. Patients from group 2 showed a 2+/-3 letters respond.
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