May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Correlation Between Central Macular Thickness, Measured by Spectral Domain OCT, Microperimetry, and Visual Acuity Loss in Type 2 Diabetic Patients With Macular Edema
Author Affiliations & Notes
  • A. R. Santos
    AIBILI, Coimbra, Portugal
    CEC,
  • S. Nunes
    AIBILI, Coimbra, Portugal
    CNTM,
  • M. Silva
    AIBILI, Coimbra, Portugal
    CEC,
  • R. Bernardes
    AIBILI, Coimbra, Portugal
    CNTM,
    IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • I. Pereira
    AIBILI, Coimbra, Portugal
    CNTM,
  • J. Cunha-Vaz
    AIBILI, Coimbra, Portugal
    IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Footnotes
    Commercial Relationships  A.R. Santos, None; S. Nunes, None; M. Silva, None; R. Bernardes, None; I. Pereira, None; J. Cunha-Vaz, Allergan, C; Eli-Lilly, C; Merck, C; Pfizer, C; Servier, C; Zeiss, C.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3500. doi:https://doi.org/
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      A. R. Santos, S. Nunes, M. Silva, R. Bernardes, I. Pereira, J. Cunha-Vaz; Correlation Between Central Macular Thickness, Measured by Spectral Domain OCT, Microperimetry, and Visual Acuity Loss in Type 2 Diabetic Patients With Macular Edema. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3500. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To establish the correlation between Visual Acuity (VA), Microperimetry (MP) and Retinal Thickness (RT) in patients with Macular Edema (ME) involving the foveal region (within the central 300µm).

Methods: : Patients’ eyes with clinically significant diabetic macular edema (CSME) (n=12), and sub-clinical diabetic macular edema (n=12) underwent RT measurements (CIRRUS HD-OCT, Zeiss), VA assessment (BCVA using ETDRS scale) and Microperimetry (MP-1, Nidek).RT maps were created within the 300µm centered on the fovea. These maps consist of 10µm concentric rings divided in 4 quadrants, plus one central area of 50µm.A new perimetric strategy was created consisting of a grid of 1º diameter with 25 stimuli - stimuli size Goldmann III, to permit a comparison between the OCT maps and MP.RT values were compared with a control population and ME was correlated with VA and Microperimetry using Spearman correlation coefficient.

Results: : The results showed a good and strong correlation between RT and both VA and MP (R= -0.829, p=0.001; R= -0.624, p=0.030, respectively) Data showed that when the thickness of the fovea increases, the VA and luminous sensitivity decreases.VA shows also a good correlation with MP (R= 0.799, p=0.002).With this type of retinal thickness maps, it is possible to isolate data from different areas in the central 300µm to correlate with VA. All eyes that present a mean RT <250µm (n=7) in the 4 quadrants showed a VA >80 letters, while the eyes presenting retinal edema in at least 3 quadrants with RT >250µm had a VA <77 letters. (p=0.001)

Conclusions: : The new spectral domain OCT technique (CIRRUS HD-OCT) permits more detailed information on the thickness of the central region of the macula. High- Definition OCT, used in conjunction with VA and MP, shows good structure-function correlation even in cases of sub-clinical ME.

Keywords: edema • visual acuity • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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