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A. R. Santos, S. Nunes, M. Silva, R. Bernardes, I. Pereira, J. Cunha-Vaz; Correlation Between Central Macular Thickness, Measured by Spectral Domain OCT, Microperimetry, and Visual Acuity Loss in Type 2 Diabetic Patients With Macular Edema. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3500.
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© ARVO (1962-2015); The Authors (2016-present)
To establish the correlation between Visual Acuity (VA), Microperimetry (MP) and Retinal Thickness (RT) in patients with Macular Edema (ME) involving the foveal region (within the central 300µm).
Patients’ eyes with clinically significant diabetic macular edema (CSME) (n=12), and sub-clinical diabetic macular edema (n=12) underwent RT measurements (CIRRUS HD-OCT, Zeiss), VA assessment (BCVA using ETDRS scale) and Microperimetry (MP-1, Nidek).RT maps were created within the 300µm centered on the fovea. These maps consist of 10µm concentric rings divided in 4 quadrants, plus one central area of 50µm.A new perimetric strategy was created consisting of a grid of 1º diameter with 25 stimuli - stimuli size Goldmann III, to permit a comparison between the OCT maps and MP.RT values were compared with a control population and ME was correlated with VA and Microperimetry using Spearman correlation coefficient.
The results showed a good and strong correlation between RT and both VA and MP (R= -0.829, p=0.001; R= -0.624, p=0.030, respectively) Data showed that when the thickness of the fovea increases, the VA and luminous sensitivity decreases.VA shows also a good correlation with MP (R= 0.799, p=0.002).With this type of retinal thickness maps, it is possible to isolate data from different areas in the central 300µm to correlate with VA. All eyes that present a mean RT <250µm (n=7) in the 4 quadrants showed a VA >80 letters, while the eyes presenting retinal edema in at least 3 quadrants with RT >250µm had a VA <77 letters. (p=0.001)
The new spectral domain OCT technique (CIRRUS HD-OCT) permits more detailed information on the thickness of the central region of the macula. High- Definition OCT, used in conjunction with VA and MP, shows good structure-function correlation even in cases of sub-clinical ME.
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