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L. E. Ernst, L. T. Sinnott, M. D. Bailey; Ciliary Body Thickness, Refractive Error, and Axial Length in Adults. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3580.
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A previous study reported increasing ciliary body thickness with increasing levels of myopia using ultrasound biomicroscopy. The purpose of this study was to determine the relationship between ciliary body thickness and refractive error in adults using the Zeiss VisanteTM Anterior Segment OCT.
Thirty-five subjects between the ages of 20 and 39 years with varying refractive error (range: –8.53 to +3.13) were included in the analysis. Cycloplegic refractive error was measured using a Grand Sieko autorefractor, axial length was measured with the IOLMaster, and images of the nasal ciliary body where obtained through the sclera while the subject fixated on a peripheral target. Ciliary body measurements were taken 2 mm (CB2) posterior to the scleral spur. Multilevel regression models were used to define the relationship between ciliary body thickness, refractive error, and axial length.
The relationship between ciliary body thickness and refractive error was not linear; the quadratic term in refractive error was significant (p < 0.001), indicating that ciliary body thickness was greatest in those with low to moderate levels of myopia. Also, the relationship between ciliary body thickness and axial length was not linear; the quadratic term in axial length was significant (p = 0.003), indicating that ciliary body thickness was greatest at moderate values of axial length.
The ciliary body is thicker in patients with of low to moderate myopia; in higher levels of myopia and the largest axial lengths, however, ciliary body thickness is similar to that found in emmetropia. Further studies are needed to determine if thicker ciliary bodies are related to the etiology of myopia and if differences in the etiology exist for low to moderate myopia as opposed to high myopia.
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