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M. Izumi, A. Maeda, S. Ijiri, S. Ohkubo, T. Higashide, K. Sugiyama; Comparison of Retinal Nerve Fiber Layer (RNFL) Thickness and Rim Area Between Superior Segmental Optic Hypoplasia (SSOH) and Normal Tension Glaucoma (NTG) With Inferior Visual Field Loss. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3634. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the RNFL thickness and rim area between SSOH and NTG with inferior visual field loss.
Seventeen SSOH patients ranged in age from 9 to 38 (mean ± standard deviation (SD), 23.8 ± 8.8 years old) and twenty-five NTG patients ranged in age from 40 to 86 (58.7 ± 10.7 years old) with inferior visual field loss were included. Optical Coherence Tomography (OCT) 3000 and Heidelberg Retina Tomograph (HRT) were used to evaluate the peripapillaly RNFL (fast RNFL thickness 3.4) and the rim area, respectively. One eye of each patient was selected based on the degree of visual field loss and reliability of visual field tests or the imaging tests. The degree of inferior visual field loss was similar between two groups. Mean deviation (MD) of Humphrey visual field analyzer (HFA) central 30-2 program was -6.7 ± 4.83 dB in the SSOH group and was -6.1 ± 4.28 dB in the NTG group, respectively. The RNFL thickness and the rim area were compared between the two groups.
There was no significant difference in the mean RNFL thickness between the SSOH and the NTG groups. The RNFL thickness at superior and nasal quadrants in the SSOH group were significantly thinner than that of NTG group (p < 0.001).The superior/inferior sector ratio and nasal/temporal sector ratio of RNFL thickness in the SSOH group were significantly smaller than those of NTG group (p < 0.01 and p < 0.001). There was no significant difference in the mean rim area between the SSOH group and the NTG group. The eyes of SSOH had significantly smaller rim area at nasal and nasal-superior sector than that of NTG group (p < 0.01). The nasal-superior/temporal-superior sector ratio and nasal/temporal sector ratio of the rim area in the SSOH group were significantly smaller than those of the NTG group (p < 0.001).
The eyes of SSOH group had significantly smaller RNFL thickness and rim area at nasal and superior sector than those of NTG group with inferior visual field loss. OCT and HRT are useful for discriminating SSOH from NTG with similar visual field loss.
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