May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Correlations Between the Individual Risk for Glaucoma and Rnfl and Optic Disc Evaluations by Means of Oct, Gdx and Hrt in Ocular Hypertensive Patients
Author Affiliations & Notes
  • L. Colombo
    Eye Clinic, Policlinico di Monza-Univ Milano Bicocca, Monza (MI), Italy
  • F. Bertuzzi
    Eye Clinic, Policlinico di Monza-Univ Milano Bicocca, Monza (MI), Italy
  • E. Rulli
    Biostatistics, Istituto Mario Negri, Milano, Italy
  • S. Miglior
    Eye Clinic, Policlinico di Monza-Univ Milano Bicocca, Monza (MI), Italy
  • Footnotes
    Commercial Relationships  L. Colombo, None; F. Bertuzzi, Pfizer, R; E. Rulli, None; S. Miglior, Pfizer, Merck, Alcon, Zeiss, Heidelberg Engineering, R.
  • Footnotes
    Support  MURST 60%, 2006
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3646. doi:https://doi.org/
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      L. Colombo, F. Bertuzzi, E. Rulli, S. Miglior; Correlations Between the Individual Risk for Glaucoma and Rnfl and Optic Disc Evaluations by Means of Oct, Gdx and Hrt in Ocular Hypertensive Patients. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3646. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the correlation between the 5-year risk of developing POAG (as calculated by the OHTS-EGPS risk calculator) and the optic nerve head and RNFL morphometrical indices as evaluated by Stratus OCT, GDx ECC, HRT III in Ocular Hypertensive (OHT) patients.

Methods: : Seventy two OHT patients with an untreated IOP between 22 and 32 mmHg in both eyes, an ophthalmoscopically normal optic disc with a c/d ratio asymmetry between the two eyes ≤ 0.2, and a visual field with GHT within normal limits, and normal PSD were enrolled. A comprehensive glaucoma work-up and examination by means of OCT, GDx ECC and HRT III were performed in all of the patients. Probability of developing POAG in 5 years was calculated by means of the OHTS-EGPS risk calculator (RC score), which has been developed by the OHTS-EGPS Collaborative Study Group by taking into account Age, and the mean values of CCT, IOP, PSD and C/D ratio collected in the two eyes. Correlations between the individual risk estimate and the OCT, GDx and HRT parameters were then assessed by regression analysis (exponential and linear), with a statistically significant level of p < 0.01.

Results: : Mean age was 62.1 (sd 9.6), mean IOP was 23.4 (sd 2), mean CCT was 569.6 (sd 33.01), mean c/d ratio was 0.38 (sd 0.17), and mean PSD was 1.79 (sd 0.44). The individual risk of the 72 patients ranged between 1.5 and 28.6%, with a mean of 10.2% (sd 6.4). Only OCT RNFL-related parameters showed a statistically significant correlation with the RC score. Average RNFL Thickness had an exponential regression r2 of 0.21 (p<0.0001) and a linear regression r2 of 0.14 (p=0.0012); Superior Average RNFL Thickness had an exponential regression r2 of 0.26 (p<0.0001) and a linear regression r2 of 0.23 (p<0.0001); Nasal Average RNFL Thickness only had an exponential regression r2 of 0.12 (p=0.0031). Neither GDx RNFL-related parameters, nor HRT disc-related parameters showed statistically significant correlations with RC score.

Conclusions: : This explorative study showed that the individual risk to develop POAG within 5 years in OHT individuals is statistically significantly correlated with OCT RNFL parameters, but not with GDx RNFL parameters or HRT disc parameters. OCT parameters could explain about 20-25% of the variability in individual RC score. The RC score seems to take into account sub-clinical RNFL thinning shown by the OCT.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • imaging/image analysis: clinical • nerve fiber layer 
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