May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Detection of Progression With HRT’s Topographic Change Analysis
Author Affiliations & Notes
  • E. Ayala
    Institut Catala de Retina, Barcelona, Spain
  • A. Anton
    Institut Catala de Retina, Barcelona, Spain
    Hospital de la Esperanza, Barcelona, Spain
  • B. Martin
    IOBA-University of Valladolid, Valladolid, Spain
  • M. Pazos
    Institut Catala de Retina, Barcelona, Spain
    Hospital de la Esperanza, Barcelona, Spain
  • J. Bardavio
    Institut Catala de Retina, Barcelona, Spain
  • M. Castany
    Hospital de la Esperanza, Barcelona, Spain
  • J. M. Navero
    Institut Catala de Retina, Barcelona, Spain
  • P. Martinez
    Institut Catala de Retina, Barcelona, Spain
  • M. Fallon
    Institut Catala de Retina, Barcelona, Spain
    Hospital de la Esperanza, Barcelona, Spain
  • A. Morilla-Grasa
    Institut Catala de Retina, Barcelona, Spain
  • Footnotes
    Commercial Relationships  E. Ayala, None; A. Anton, None; B. Martin, None; M. Pazos, None; J. Bardavio, None; M. Castany, None; J.M. Navero, None; P. Martinez, None; M. Fallon, None; A. Morilla-Grasa, None.
  • Footnotes
    Support  FIS PI061167 and MSD Spain
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3651. doi:https://doi.org/
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    • Get Citation

      E. Ayala, A. Anton, B. Martin, M. Pazos, J. Bardavio, M. Castany, J. M. Navero, P. Martinez, M. Fallon, A. Morilla-Grasa; Detection of Progression With HRT’s Topographic Change Analysis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3651. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the capabilities of the Topographic Change Analysis (TCA) of HRT to detect structural changes in glaucoma damage.

Methods: : Prospective study. Minimum follow up of 36 months. Fifty four eyes with diagnosis of glaucomatous optic neuropathy were included in this study. All subjects were examined with Humphrey perimetry (24-2 SITA standard) every six months, disc photographs and Confocal Scanning Laser Ophthalmoscopy (HRT-III, Heidelberg Engineering) once a year. Only eyes with good quality images (SD < 25µ) and reliable fields were included.

Results: : Twenty nine eyes had at least 4 HRT good quality images and 6 fields and were used for all calculations. The other 25 eyes were excluded due to insufficient quality of images or fields. Six eyes (20%) showed confirmed progression on visual fields, 5 eyes (17%) progressed according to classification changes on MRA classification, 20 eyes (68%) had a significant cluster by TCA when confirmed in two images, and 9 eyes (31%) showed a significant TCA cluster confirmed in 3 images. Finally, 5 eyes (17%) progressed in both fields and HRT.

Conclusions: : HRT detected progression in 31 to 68% of eyes after 3 years of follow up. Eighty percent of eyes with field progression showed progression on HRT.

Keywords: imaging/image analysis: clinical • clinical (human) or epidemiologic studies: systems/equipment/techniques • optic disc 
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