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E. Ayala, A. Anton, B. Martin, M. Pazos, J. Bardavio, M. Castany, J. M. Navero, P. Martinez, M. Fallon, A. Morilla-Grasa; Detection of Progression With HRT’s Topographic Change Analysis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3651.
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To evaluate the capabilities of the Topographic Change Analysis (TCA) of HRT to detect structural changes in glaucoma damage.
Prospective study. Minimum follow up of 36 months. Fifty four eyes with diagnosis of glaucomatous optic neuropathy were included in this study. All subjects were examined with Humphrey perimetry (24-2 SITA standard) every six months, disc photographs and Confocal Scanning Laser Ophthalmoscopy (HRT-III, Heidelberg Engineering) once a year. Only eyes with good quality images (SD < 25µ) and reliable fields were included.
Twenty nine eyes had at least 4 HRT good quality images and 6 fields and were used for all calculations. The other 25 eyes were excluded due to insufficient quality of images or fields. Six eyes (20%) showed confirmed progression on visual fields, 5 eyes (17%) progressed according to classification changes on MRA classification, 20 eyes (68%) had a significant cluster by TCA when confirmed in two images, and 9 eyes (31%) showed a significant TCA cluster confirmed in 3 images. Finally, 5 eyes (17%) progressed in both fields and HRT.
HRT detected progression in 31 to 68% of eyes after 3 years of follow up. Eighty percent of eyes with field progression showed progression on HRT.
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