May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Localized Glaucomatous Change Detection Using a New Permutation Test Strategy
Author Affiliations & Notes
  • M. Balasubramanian
    Hamilton Glaucoma Center, Dept. of Ophthalmology, UCSD, La Jolla, California
  • C. Bowd
    Hamilton Glaucoma Center, Dept. of Ophthalmology, UCSD, La Jolla, California
  • G. Vizzeri
    Hamilton Glaucoma Center, Dept. of Ophthalmology, UCSD, La Jolla, California
  • P. A. Sample
    Hamilton Glaucoma Center, Dept. of Ophthalmology, UCSD, La Jolla, California
  • R. N. Weinreb
    Hamilton Glaucoma Center, Dept. of Ophthalmology, UCSD, La Jolla, California
  • N. O'Leary
    Optometry and Visual Science, City University, London, United Kingdom
  • D. P. Crabb
    Optometry and Visual Science, City University, London, United Kingdom
  • D. F. Garway-Heath
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
  • L. M. Zangwill
    Hamilton Glaucoma Center, Dept. of Ophthalmology, UCSD, La Jolla, California
  • Footnotes
    Commercial Relationships  M. Balasubramanian, Heidelberg Engineering, F; C. Bowd, Lace Elettronica, F; G. Vizzeri, None; P.A. Sample, Carl Zeiss Meditec, F; Haag-Streit, F; Welch-Allyn, F; R.N. Weinreb, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Carl Zeiss Meditec, C; N. O'Leary, None; D.P. Crabb, None; D.F. Garway-Heath, Carl Zeiss Meditec, R; Heidelberg Engineering, F; Carl Zeiss Meditec, F; Optovue, F; Carl Zeiss Meditec, C; L.M. Zangwill, Heidelberg Engineering, F; Carl Zeiss Meditec, F; Optovue, F.
  • Footnotes
    Support  NEI EY08208 (PAS), NEI EY11008 (LMZ), and participant incentive grants in the form of glaucoma medication at no cost from Alcon Laboratories Inc, Allergan, Pfizer Inc., and SANTEN Inc.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3652. doi:
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    • Get Citation

      M. Balasubramanian, C. Bowd, G. Vizzeri, P. A. Sample, R. N. Weinreb, N. O'Leary, D. P. Crabb, D. F. Garway-Heath, L. M. Zangwill; Localized Glaucomatous Change Detection Using a New Permutation Test Strategy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3652.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To evaluate a new superpixel progression event analysis based on re-sampling (SPEAR) to detect localized glaucomatous changes in HRT topographs.

 
Methods:
 

Topographic change analysis (TCA) and statistic image mapping of the retina (SIM) methods are available for detecting localized changes. Unlike TCA, SIM controls for family-wise type-I errors, but requires ≥ 2 follow-ups. SPEAR addresses each of these limitations. Topograph locations were grouped into superpixels (SP) as in TCA. Change significance in each SP between one baseline and each follow-up was estimated from a re-sampling distribution of normalized mean differences. Topograph level changes were detected using a supra-threshold cluster test and the largest cluster size within the optic disk margin (cszSPEAR) and the associated change probability (pSPEAR) were computed. SPEAR parameters were compared with the largest red-pixel cluster size within the optic disk margin in TCA (cszTCA) and evaluated using two independent datasets: 1) from the UCSD Diagnostic Innovations in Glaucoma Study (DIGS) and 2) from the Moorfields Eye Hospital (MF). Of the 240 eyes from 143 DIGS glaucoma patients and suspects with ≥ 4 HRT-II exams, 36 eyes progressed by stereophotos or showed likely progression on visual field guided progression analysis (digsProg). All other eyes were considered to be non-progressing (digsNonProg; n = 204). HRT exams from 20 normal eyes (mfNonProg) and 32 ocular hypertensive eyes that developed visual field changes (mfProg) from the MF were also analyzed.

 
Results:
 

 

 
Keywords: imaging/image analysis: non-clinical • computational modeling 
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