May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Glaucoma Detection Using Fourier-Domain Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoscopy
Author Affiliations & Notes
  • E. M. Hoffmann
    University of Mainz, Mainz, Germany
    Ophthalmology,
  • S. Aliyeva
    University of Mainz, Mainz, Germany
    Ophthalmology,
  • M. Berres
    University of Mainz, Mainz, Germany
    Medical Biometry, Epidemiology, Informatics,
  • H. Thieme
    University of Mainz, Mainz, Germany
    Ophthalmology,
  • N. Pfeiffer
    University of Mainz, Mainz, Germany
    Ophthalmology,
  • Footnotes
    Commercial Relationships  E.M. Hoffmann, research support in the form of instruments at no costs (Optovue, Inc), F; S. Aliyeva, None; M. Berres, None; H. Thieme, None; N. Pfeiffer, research support in the form of instruments at no costs (Optovue, Inc), F.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3659. doi:
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    • Get Citation

      E. M. Hoffmann, S. Aliyeva, M. Berres, H. Thieme, N. Pfeiffer; Glaucoma Detection Using Fourier-Domain Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3659.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the diagnostic precision for glaucoma detection using Fourier / spectral-domain optical coherence tomography (RTVue, Optovue, Inc. Freemont, USA) and confocal sanning laser ophthalmoscopy (HRT 3, Heidelberg Engineering, Germany).

Methods: : 40 early glaucoma patients and 20 healthy subjects were included. All patients and subjects underwent RTVue and HRT 3 imaging on the same day. Glaucoma diagnosis was based on the visual field glaucoma staging system according to Brusini. Receiver operating characteristic (ROC) curve areas were analysed to evaluate the diagnostic performance of both technologies.

Results: : The best parameter for glaucoma detection using the RTVue was mean retinal nerve fiber layer thickness (mean RNFL) with an ROC curve area of 0.8 followed by rim area and vertical cup disc area ratio measurements (ROC curve areas 0.78). The best parameter using the HRT 3 was rim area with an ROC curve area of 0.75 followed by rim volume and mean RNFL measurements (ROC curve areas 0.68 and 0.67, respectively).

Conclusions: : Domain Fourier optical coherence tomography performed comparable to confocal scanning laser ophthalmoscopy in diagnosing early glaucoma. This new technology may prove to be a useful tool in detection of glaucoma.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc • clinical (human) or epidemiologic studies: systems/equipment/techniques 
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