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E. M. Hoffmann, S. Aliyeva, M. Berres, H. Thieme, N. Pfeiffer; Glaucoma Detection Using Fourier-Domain Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3659.
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To evaluate the diagnostic precision for glaucoma detection using Fourier / spectral-domain optical coherence tomography (RTVue, Optovue, Inc. Freemont, USA) and confocal sanning laser ophthalmoscopy (HRT 3, Heidelberg Engineering, Germany).
40 early glaucoma patients and 20 healthy subjects were included. All patients and subjects underwent RTVue and HRT 3 imaging on the same day. Glaucoma diagnosis was based on the visual field glaucoma staging system according to Brusini. Receiver operating characteristic (ROC) curve areas were analysed to evaluate the diagnostic performance of both technologies.
The best parameter for glaucoma detection using the RTVue was mean retinal nerve fiber layer thickness (mean RNFL) with an ROC curve area of 0.8 followed by rim area and vertical cup disc area ratio measurements (ROC curve areas 0.78). The best parameter using the HRT 3 was rim area with an ROC curve area of 0.75 followed by rim volume and mean RNFL measurements (ROC curve areas 0.68 and 0.67, respectively).
Domain Fourier optical coherence tomography performed comparable to confocal scanning laser ophthalmoscopy in diagnosing early glaucoma. This new technology may prove to be a useful tool in detection of glaucoma.
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