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D. Nankivil, D. Borja, K. Ehrmann, S. Uhlhorn, E. Arrieta-Quintero, A. Ho, F. Manns, J.-M. Parel; Change in Lens Profile During Simulated Accommodation: The Effect of Anterior Zonule Transection. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3784.
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To quantify the role of anterior zonular tension on the lens radius of curvature during simulation of accommodation in a lens stretcher.
One post-mortem cynomolgus monkey eye (7 year old) was dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous and a segmented scleral rim. The lens preparation was mounted in an optomechanical lens stretching system (EVAS II, Ehrmann et al, SPIE Proceedings Vol 5314) and the sclera was stretched 3mm radially in a step-wise fashion (0.5mm/step). The load was recorded at each step, as well as images of the entire crystalline lens acquired using a custom-made Optical Coherence Tomography (OCT) system. The OCT images were processed to calculate the anterior and posterior radii of curvature of the lens at each step. The anterior zonular fibers were then carefully transected using a diamond blade and the experiment was repeated. The changes in the radii-load relationship before and after transection of the zonules were compared.
Stretching increased the anterior and posterior radius of curvature of the lens by 9.44±0.17mm and 1.34±0.04mm before zonular transection and 4.09±0.07mm and 1.92±0.04mm after zonular transection. The radius of the anterior surface increased linearly as the load increased, with a slope of 2.57±0.36mm/g before and 1.58±0.25mm/g after zonular transection. Similarly, the radius of curvature of the posterior surface increased with a slope of 0.39±0.06mm/g before and 0.76±0.08mm/g after zonular transection.
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