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H.-K. Kuo, M.-T. Kuo, P.-C. Wu, Y.-H. Chen; The Interocular Amplitude Ratio of Flicker Electroretinogram Is a Strong Prognostic Indicator of Neovascularization in Central Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3806.
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to evaluate the prognostic value of flicker electroretinogram (ERG) in case of CRVO regarding the development of neovascularization (NV).
Retrospectively review the data of scotopic flicker ERG of 69 CRVO patients. The fellow eye was treated as the normal control. 24 patients that had enough follow up to be adjusted as ischemia (I) or nonischemia (N) were treated as the study group.
In the control eyes, age statistically influenced the latency (p=0.018), but not the amplitude (p=0.756). In the study group, 10 eyes were ischemic and suffered from vitreous hemorrhage or neovascular glaucoma. Another 14 eyes were nonischemia. The latency value of I group located at both tails of normal data, but, the mean value of interocular latency difference (lesion eye and fellow eye) between I and N group was not statistically different. The interocular amplitude difference and amplitude ratio between I and N groups were statistically strongly different (p<0.000).
The amplitude of flicker electroretinogram is a good prognostic indicator of neovascularization in central retinal vein occlusion.
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