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J. Nilsson, T. Wright, C. A. Westall; Bright Flash Rod Response Adds Information on Rod System Function in 25% of Recorded Eyes. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3812.
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The scotopic b-wave response, commonly called the rod ERG, is the standard measure of rod function in clinical ERG testing. The scotopic b-wave response may not be the optimum measure of rod activity. Analysis of high intensity flash a-waves (bright flash ERG) is an additional method of assessing the rod system. This study compares information obtained with rod ERG with that obtained by bright flash ERG.
The bright flash ERG protocol was added to all clinical ERG protocols in our lab. A total of 2396 eyes were recorded. Patient age ranged from 2.4 months to 84.6 years.
Bright flash ERG provided additional information on rod system function above that obtained with rod ERG in 25% of eyes recorded, most importantly in subjects with midretinal disease and artificially reduced rod responses. Bright flash ERG also provided a measurable response for longitudinal monitoring in rod dystophies with non-recordable rod ERGs. Results from patients with normal standard ERG results provided information on development of the rod photoreceptor response; bright flash response matures at 3-4 years of age and remains stable throughout adult life.
The bright flash protocol is a valuable tool for assessing rod system function in a wide set of retinal diseases and testing situations. Clinical ERG testing would benefit greatly from adding the bright flash protocol to its standard testing conditions.
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