May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
Arrangement of the Human Trichromatic Cone Mosaic in Peripheral Retina
Author Affiliations & Notes
  • O. Masuda
    Ctr for Vis Science, University of Rochester, Rochester, New York
  • H. Hofer
    College of Optometry, University of Houston, Houston, Texas
  • J. Carroll
    Department of Ophthalmology, The Medical College of Wisconsin, Milwaukee, Wisconsin
  • D. R. Williams
    Ctr for Vis Science, University of Rochester, Rochester, New York
  • Footnotes
    Commercial Relationships  O. Masuda, None; H. Hofer, None; J. Carroll, None; D.R. Williams, Optos, Inc., C; adaptive optics, P.
  • Footnotes
    Support  NIH EY04367, NIH EY01319 and the NSF Science and Technology Center for Adaptive Optics (cooperative agreement no.: AST-9876783 with UCSC)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3832. doi:
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    • Get Citation

      O. Masuda, H. Hofer, J. Carroll, D. R. Williams; Arrangement of the Human Trichromatic Cone Mosaic in Peripheral Retina. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3832.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Previous studies have concluded that the packing arrangement of L and M cones near the center of the human fovea is not distinguishable from random in most eyes. We sought to determine whether this is also true for extrafoveal retina.

Methods: : We classified the L, M, and S cones in one female color-normal subject with adaptive optics imaging combined with retinal densitometry at 1.25 , 4, and 10 deg in the temporal retina. We evaluated the packing arrangement of the 3 cone classes by comparing the frequencies of distances between all cones of the same type with those expected based on a random pigment assignment rule.

Results: : 314 cones were classified at 10 deg, 739 at 4 deg, and 1456 at 1.25 deg. The number of misidentified L and M cones at each location was estimated at 3.9 %, 2.8 %, and 2.5 % respectively. Though the ratio of L to M cones did not differ significantly across the eccentricities tested, peripheral L and M cones exhibited significant clumping whereas those at 1.25 deg did not.

Conclusions: : The organization of L and M cones outside the fovea, at least in one subject, shows a clear tendency toward clumping of cones of like type. This clumping may have implications for the strength of red-green color vision in peripheral retina since it increases the probability that peripheral midget cell centers will be driven by predominantly one class of cone.

Keywords: retina • color vision • receptors 

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