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R. Messaoud, S. Attia, S. Zaouali, B. Jelliti, S. Jenzeri, M. Khairallah; Choroidal Vascular Involvement in Patients With Acute Vogt-Koyanagi-Harada Disease. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3887. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze choroidal vascular involvement in acute Vogt-Koyanagi-Harada (VKH) disease.
The study included 13 consecutive patients (26 eyes) with acute VKH disease. All patients underwent a complete ophthalmic evaluation that included measurement of best-corrected visual acuity, slit-lamp examination, and dilated fundus examination with contact lenses. Fundus photography, fluorescein angiography, and indocyanine green (ICG) angiography were performed in all cases.
Eyes were affected as follows: choriocapillaris filling delay/defects (26; 100%), a decrease in the number of large choroidal vessels (10; 38.5%), perivascular leakage (24; 92.3%), areas of choroidal hyperfluorescence in the late phase of ICG angiography (20; 76.9%), and severe thrombosis of large choroidal vessels (2; 7.7%).
Choroidal vasculopathy, with features of choroidal ischemia and vascular hyperpermeabilty, appears to be a prominent finding in patients with acute VKH disease. ICG angiography could be a useful tool in detecting and monitoring choroidal vasculopathy in patients with acute VKH disease.
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