Abstract
Purpose: :
To analyze choroidal vascular involvement in acute Vogt-Koyanagi-Harada (VKH) disease.
Methods: :
The study included 13 consecutive patients (26 eyes) with acute VKH disease. All patients underwent a complete ophthalmic evaluation that included measurement of best-corrected visual acuity, slit-lamp examination, and dilated fundus examination with contact lenses. Fundus photography, fluorescein angiography, and indocyanine green (ICG) angiography were performed in all cases.
Results: :
Eyes were affected as follows: choriocapillaris filling delay/defects (26; 100%), a decrease in the number of large choroidal vessels (10; 38.5%), perivascular leakage (24; 92.3%), areas of choroidal hyperfluorescence in the late phase of ICG angiography (20; 76.9%), and severe thrombosis of large choroidal vessels (2; 7.7%).
Conclusions: :
Choroidal vasculopathy, with features of choroidal ischemia and vascular hyperpermeabilty, appears to be a prominent finding in patients with acute VKH disease. ICG angiography could be a useful tool in detecting and monitoring choroidal vasculopathy in patients with acute VKH disease.
Keywords: inflammation • choroid