May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Relationship Between the Roughness of Corneal Epithelium and the Transmission of Light
Author Affiliations & Notes
  • P. Perez-Merino
    University of Valladolid, Valladolid, Spain
    Instituto de Oftalmobiología Aplicada, IOBA,
  • C. Martinez-Garcia
    University of Valladolid, Valladolid, Spain
    Departamento de Biología Celular,
  • S. Mar-Sardaña
    University of Valladolid, Valladolid, Spain
    Departamento de Física Teórica, Atómica y Óptica,
  • A. Perez-Escudero
    Instituto de Óptica, CSIC, Madrid, Spain
  • J. Merayo-Lloves
    University of Valladolid, Valladolid, Spain
    Instituto de Oftalmobiología Aplicada, IOBA,
  • T. Blanco-Mezquita
    University of Valladolid, Valladolid, Spain
    Instituto de Oftalmobiología Aplicada, IOBA,
  • E. Garrido-Calvo
    University of Valladolid, Valladolid, Spain
    Departamento de Física Teórica, Atómica y Óptica,
  • Footnotes
    Commercial Relationships  P. Perez-Merino, None; C. Martinez-Garcia, None; S. Mar-Sardaña, None; A. Perez-Escudero, None; J. Merayo-Lloves, None; T. Blanco-Mezquita, None; E. Garrido-Calvo, None.
  • Footnotes
    Support  This work was supported by a grant from the Spanish Ministery of Health (Fondo de Investigación Sanitaria FIS 05/2841).
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3910. doi:https://doi.org/
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      P. Perez-Merino, C. Martinez-Garcia, S. Mar-Sardaña, A. Perez-Escudero, J. Merayo-Lloves, T. Blanco-Mezquita, E. Garrido-Calvo; Relationship Between the Roughness of Corneal Epithelium and the Transmission of Light. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3910. doi: https://doi.org/.

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Abstract

Purpose: : To determine the relationship among transmittance, scattering and epithelial surface properties during wound healing after refractive surgery.

Methods: : Hens operated by different techniques (Lasik, Lasek, PRK), and a group of hens with only epithelial corneal removal but not laser excimer application, were permitted to heal for 30 days. Transmittance and scattering were measured by a scatterometer developed by our group. External and internal roughness and thickness of epithelium were assessed by custom routines developed for quantitative analysis of microphotographs of corneal epithelium.

Results: : Data analysis showed that the epithelial thickness has no influence onthe transmittance. However, higher roughness in the epithelium-stroma interface causes a decrease of transmittance and an increase of scattering. Larger differences between internal and external roughness of epithelium contributes to produce a decrease of transmittance and an increase of scattered light.

Conclusions: : Roughness of epithelial surfaces is directly related to the transmittance and light scattering in the cornea.

Keywords: wound healing • refractive surgery • cornea: epithelium 
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