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T. Senoo, M. Takayama, K. Chiba; The Affects of the Oxidative Stress in Bullous Keratopathy Patients After Argon Laser Iridotomy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3935.
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© ARVO (1962-2015); The Authors (2016-present)
While argon laser iridotomy (ALI) is one of the safety methods for closed angle glaucoma, it sometimes causes corneal endothelial decompensation and bullous keratopathy (BK). But this mechanism is still unclear. In this study, the affects of the oxidative stress in BK patients after ALI were evaluated.
1) 2 kg of Dutch Rabbits were prepared. The peroxidative reaction was evaluated at just, 3rd and 7th day after ALI or Nd-YAG LI by Superoxide dismutase activity (SOD activity). 2) The records were studied of 10 BK patients (71+/- 7.2 years of age) and 11 non-BK patients (70+/- 7.3 years of age) after ALI. Oxidative stress levels and Anti-oxidative stress levels were assessed with d-ROMs test and BAP test (Diacron;Grosseto, Italy).
1) The SOD activity was increased at just and 3rd day after ALI and Nd-YAG LI. 2) Oxidative stress levels were higher in BK compared to non-BK patients (mean +/- SD stress level, 405.8 +/- 127.3 vs 309.2 +/- 49.4 UCarr, respectively;p < 0.05). Anti-oxidative stress levels were lower in BK compared to non-BK patients (mean +/- SD anti-stress level, 1832.6 +/- 188.6 vs 2211.3 +/- 72.1 uM, respectively;p < 0.0001).
These results suggested that, the peroxidative reaction was occurred after LI, and the patient who is vulnerable in oxidative stress is easy to become BK.
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