May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
The Affects of the Oxidative Stress in Bullous Keratopathy Patients After Argon Laser Iridotomy
Author Affiliations & Notes
  • T. Senoo
    Ophthalmology, Dokkyo Univ School of Medicine, Shimotsuga-Gun, Japan
  • M. Takayama
    Ophthalmology, Dokkyo Univ School of Medicine, Shimotsuga-Gun, Japan
  • K. Chiba
    Ophthalmology, Dokkyo Univ School of Medicine, Shimotsuga-Gun, Japan
  • Footnotes
    Commercial Relationships  T. Senoo, None; M. Takayama, None; K. Chiba, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3935. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T. Senoo, M. Takayama, K. Chiba; The Affects of the Oxidative Stress in Bullous Keratopathy Patients After Argon Laser Iridotomy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3935. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : While argon laser iridotomy (ALI) is one of the safety methods for closed angle glaucoma, it sometimes causes corneal endothelial decompensation and bullous keratopathy (BK). But this mechanism is still unclear. In this study, the affects of the oxidative stress in BK patients after ALI were evaluated.

Methods: : 1) 2 kg of Dutch Rabbits were prepared. The peroxidative reaction was evaluated at just, 3rd and 7th day after ALI or Nd-YAG LI by Superoxide dismutase activity (SOD activity). 2) The records were studied of 10 BK patients (71+/- 7.2 years of age) and 11 non-BK patients (70+/- 7.3 years of age) after ALI. Oxidative stress levels and Anti-oxidative stress levels were assessed with d-ROMs test and BAP test (Diacron;Grosseto, Italy).

Results: : 1) The SOD activity was increased at just and 3rd day after ALI and Nd-YAG LI. 2) Oxidative stress levels were higher in BK compared to non-BK patients (mean +/- SD stress level, 405.8 +/- 127.3 vs 309.2 +/- 49.4 UCarr, respectively;p < 0.05). Anti-oxidative stress levels were lower in BK compared to non-BK patients (mean +/- SD anti-stress level, 1832.6 +/- 188.6 vs 2211.3 +/- 72.1 uM, respectively;p < 0.0001).

Conclusions: : These results suggested that, the peroxidative reaction was occurred after LI, and the patient who is vulnerable in oxidative stress is easy to become BK.

Keywords: cornea: endothelium • oxidation/oxidative or free radical damage • laser 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×