May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Pharmacological Modulation of Orbital Venous Pressure in Anesthetized Rabbits
Author Affiliations & Notes
  • C. Runge
    Ophthalmology and Optometry, Paracelsus University, Salzburg, Austria
  • B. Tockner
    Ophthalmology and Optometry, Paracelsus University, Salzburg, Austria
  • B. Bogner
    Ophthalmology and Optometry, Paracelsus University, Salzburg, Austria
  • C. Strohmaier
    Ophthalmology and Optometry, Paracelsus University, Salzburg, Austria
  • G. Grabner
    Ophthalmology and Optometry, Paracelsus University, Salzburg, Austria
  • H. Reitsamer
    Ophthalmology and Optometry, Paracelsus University, Salzburg, Austria
  • Footnotes
    Commercial Relationships  C. Runge, None; B. Tockner, None; B. Bogner, None; C. Strohmaier, None; G. Grabner, None; H. Reitsamer, None.
  • Footnotes
    Support  Fuchsstiftung, Adele Radensteiner
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4138. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      C. Runge, B. Tockner, B. Bogner, C. Strohmaier, G. Grabner, H. Reitsamer; Pharmacological Modulation of Orbital Venous Pressure in Anesthetized Rabbits. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4138. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To compare the effects of different drugs on the orbital venous pressure in anesthetized rabbits.

 
Methods:
 

Mean arterial pressure (MAP), intraocular pressure (IOP) and orbital venous pressure (OVP) were measured by direct cannulation of the central ear artery, the vitreous, and the orbital venous sinus, respectively. Laser Doppler flowmetry was used to measure choroidal blood flow invasively through the pars plana. Measurements were made continuously at baseline and after drug application.

 
Results:
 

Vasopressin has a dose dependend reducing effect on the orbital venous pressure and also the beta1 receptor antagonists Metoprolol and Nebivolol are able to reduce the orbital venous pressure. However, adenosine has an ambiguous effect, the low dose intravenous infusion (5mg/kg/h) has an increasing effect on the orbital venous pressure whereas the high dose application (10, 20, 30 mg/kg/h) decreases the orbital venous pressure.

 
Conclusions:
 

The orbital venous sinus is supplied by the big veins of the head, however, a certain portion of the blood comes from the eye and orbital venous pressure depends on ocular blood flow to a certain extent. If changes of orbital venous pressure are cause by local or systemic changes of hemodanymic parameters or both remains to be investigated.  

 
Keywords: blood supply • drug toxicity/drug effects • intraocular pressure 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×