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Y. Kitaguchi, T. Fujikado, K. Bessho, T. Yamaguchi, N. Nakazawa, Y. Hirohara, T. Mihashi, N. Maeda, Y. Tano; Reduced Photoreceptor Thickness Causes Blur of Photoreceptor Mosaic in the Image by Flood-illumination Adaptive Optics Fundus Camera. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4201.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the cause of blurred images in adaptive optics (AO) fundus camera by comparing the findings of optical coherence tomography (OCT).
Sixty eight eyes with retinal disease and 6 normal eyes in which root mean square value of the total aberration (t-RMS) was corrected below 0.2µm in 5.4mm pupil were evaluated. AO fundus camera (Topcon corp.) equipped with a 635nm luminescence diode illuminator and 768 x 768 pixel refractive liquid crystal light modulator (Hamamatsu Photonics) was used. AO images were classified into 4 groups by the sharpness of photoreceptor mosaic (PM); clear PM (n=10), slightly blurred PM (n=39), blurred PM (n=24), no PM (n=1). Retinal thickness, and the distance between the photoreceptor inner segment/outer segment junction to retinal pigment epithelium (IS/OS-RPE distance) were compared among each group. Retinal thickness and IS/OS-RPE distance were measured by OCT (Stratus OCT; Carl Zeiss ).
The IS/OS-RPE distance was significantly larger in the group of clear PM and slightly blurred PM than that in the group of blurred PM (One way ANOVA, p<0.05). No significant difference was observed in t-RMS and in retinal thickness among each group.
Reduced photoreceptor layer thickness is one of the reasons that causes AO image blurred.
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