May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Reduced Photoreceptor Thickness Causes Blur of Photoreceptor Mosaic in the Image by Flood-illumination Adaptive Optics Fundus Camera
Author Affiliations & Notes
  • Y. Kitaguchi
    Osaka Univ Med School, Suita, Japan
    Applied science,
  • T. Fujikado
    Osaka Univ Med School, Suita, Japan
    Applied science,
  • K. Bessho
    Ophthalmology, Yodogawa Christian Hospital, Suita, Japan
  • T. Yamaguchi
    Topcon Co., Suita, Japan
  • N. Nakazawa
    Topcon Co., Suita, Japan
  • Y. Hirohara
    Topcon Co., Suita, Japan
  • T. Mihashi
    Topcon Co., Suita, Japan
  • N. Maeda
    Osaka Univ Med School, Suita, Japan
    Ophthalmology,
  • Y. Tano
    Osaka Univ Med School, Suita, Japan
    Ophthalmology,
  • Footnotes
    Commercial Relationships  Y. Kitaguchi, None; T. Fujikado, None; K. Bessho, None; T. Yamaguchi, None; N. Nakazawa, None; Y. Hirohara, None; T. Mihashi, None; N. Maeda, None; Y. Tano, None.
  • Footnotes
    Support  Health Sciences Research Grants (H16-sensory-001) from the Ministry of Health, Labor and Welfare, Japan
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4201. doi:
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      Y. Kitaguchi, T. Fujikado, K. Bessho, T. Yamaguchi, N. Nakazawa, Y. Hirohara, T. Mihashi, N. Maeda, Y. Tano; Reduced Photoreceptor Thickness Causes Blur of Photoreceptor Mosaic in the Image by Flood-illumination Adaptive Optics Fundus Camera. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4201.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the cause of blurred images in adaptive optics (AO) fundus camera by comparing the findings of optical coherence tomography (OCT).

Methods: : Sixty eight eyes with retinal disease and 6 normal eyes in which root mean square value of the total aberration (t-RMS) was corrected below 0.2µm in 5.4mm pupil were evaluated. AO fundus camera (Topcon corp.) equipped with a 635nm luminescence diode illuminator and 768 x 768 pixel refractive liquid crystal light modulator (Hamamatsu Photonics) was used. AO images were classified into 4 groups by the sharpness of photoreceptor mosaic (PM); clear PM (n=10), slightly blurred PM (n=39), blurred PM (n=24), no PM (n=1). Retinal thickness, and the distance between the photoreceptor inner segment/outer segment junction to retinal pigment epithelium (IS/OS-RPE distance) were compared among each group. Retinal thickness and IS/OS-RPE distance were measured by OCT (Stratus OCT; Carl Zeiss ).

Results: : The IS/OS-RPE distance was significantly larger in the group of clear PM and slightly blurred PM than that in the group of blurred PM (One way ANOVA, p<0.05). No significant difference was observed in t-RMS and in retinal thickness among each group.

Conclusions: : Reduced photoreceptor layer thickness is one of the reasons that causes AO image blurred.

Keywords: photoreceptors • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 
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