May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Clinical Application of Adaptive Optics - Optical Coherence Tomography (AO - OCT) in Studying of Micro-Structural Changes Associated With Macular Pathologies
Author Affiliations & Notes
  • S. S. Choi
    Ophthalmology & Vision Science, Univ of California Davis Med Ctr, Sacramento, California
  • R. J. Zawadzki
    Ophthalmology & Vision Science, Univ of California Davis Med Ctr, Sacramento, California
  • S. S. Park
    Ophthalmology & Vision Science, Univ of California Davis Med Ctr, Sacramento, California
  • J. L. Keltner
    Ophthalmology & Vision Science, Univ of California Davis Med Ctr, Sacramento, California
  • J. S. Werner
    Ophthalmology & Vision Science, Univ of California Davis Med Ctr, Sacramento, California
  • Footnotes
    Commercial Relationships  S.S. Choi, None; R.J. Zawadzki, None; S.S. Park, None; J.L. Keltner, None; J.S. Werner, None.
  • Footnotes
    Support  NEI 014743, RPB
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4203. doi:https://doi.org/
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    • Get Citation

      S. S. Choi, R. J. Zawadzki, S. S. Park, J. L. Keltner, J. S. Werner; Clinical Application of Adaptive Optics - Optical Coherence Tomography (AO - OCT) in Studying of Micro-Structural Changes Associated With Macular Pathologies. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4203. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Adaptive optics-optical coherence tomography (AO-OCT) is a new imaging modality that combines the high axial resolution of Fourier-domain OCT (FD-OCT) with high transverse resolution of adaptive optics (AO). In this study, we compared the morphologic information obtained with AO-OCT to that obtained with FD-OCT for various subtle and unexplained macular pathologies.

Methods: : Patients with subtle maculopathy (diagnosed on funduscopy, fluorescein angiography and commercial FD-OCT) and/or with unexplained visual symptoms were imaged with AO-OCT and FD-OCT developed at our institution. The AO-OCT system has axial and transverse resolutions of 3 microns. It was used to zoom into macular regions of interest for detailed examination. The FD-OCT system has axial resolution of 4.5 microns and transverse resolution of 10 to 15 microns. Scans centered on the fovea were obtained and compared to images obtained using AO-OCT.

Results: : AO-OCT revealed additional micro-structures as well as more structural details that were not detected by conventional imaging systems and high resolution FD-OCT. These structures included fine intraretinal structural changes such as subtle intraretinal deposits or disruption of retinal layers. Of special interest is a case of mild bilateral juxtafoveal telangectasia diagnosed by fluorescein angiography. Her unexplained visual symptoms had no apparent morphological basis, except with AO-OCT imaging which revealed subtle deposits in the Fibers of Henle.

Conclusions: : This study demonstrated that AO-OCT has sufficient resolution to detect subtle microstructural changes associated with various macular pathologies that were not evident with other imaging systems including high resolution FD-OCT. AO-OCT may be a useful tool for furthering our understanding of various macular pathologies.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • photoreceptors • retina 
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