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L. Pelosini, J. Boyce, J. D. A. McHugh, M. Stanford, J. Marshall; The Assessment of Optical Coherence Tomography (OCT) as a Predictor of Visual Acuity in Diabetic Macular Oedema. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4236.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate whether retinal structural integrity may be a prognostic indicator in cystoid macular oedema (CMO).
The study was conducted at the Department of Ophthalmology, St Thomas’ Hospital, London. Institutional Ethics Committee approval was obtained (06/Q0702/175).127 patients underwent functional assessment (LogMAR, Bailey-Lovie charts, SLO microperimetry) and morphologic examination of the macular area with OCT/SLO imaging (OTI, Toronto). Structural integrity was measured evaluating the number, diameter and eccentricity of columns between cystoid spaces of CMO on axial and coronal OCT scans. The images were processed with an automated image analysis method.
LogMAR visual acuity (r=0.4, P<0.002), Bailey-Lovie acuity (r=0.68, P<0.0001) and contrast sensitivity (r=0.7, P<0.0008) correlated significantly with measures of tissue integrity on OCT scans. A significant inverse correlation was found between microperimetry values (r= -0.43, P<0.0001) and eccentricity of columns.
Retinal structural integrity from OCT scans may be used as a predictor of final visual outcome in cystoid macular oedema.
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