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G. Landa, P. M. T. Garcia, R. B. Rosen; Combined Three Dimensional OCT/SLO Topography and Microperimetry - The Analysis of Correlation. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4237. doi: https://doi.org/.
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Patients with various ocular diseases and patients with normal fundus underwent microperimetry test and imaging with spectral OCT/SLO (Ophthalmic Technologies Inc., Toronto, Canada) at the Retina Center of The New York Eye & Ear Infirmary, New York, USA. Three dimensional topographic thickness maps combined with microperimetry were created for each patient.All patients were divided into four groups. Group I consisted of patients with the diseases of outer retina; Group II included patients with inner retina pathology; Group III included patients with macular scarring; and Group IV consisted of patients who had unremarkable fundus appearance, normal thickness and contour of the retina on OCT.The primary outcome was the correlation coefficient (rs) between OCT/SLO measured macular thickness and microperimetry values.
Seventy six eyes of 62 consecutive patients with various ocular diseases and patients with normal fundus were examined during this prospective clinical study.There were 30 males and 32 females. Ages ranged from 24 to 91years, (mean+SD, 59.3 + 12.2 years).The analysis of overall correlation between macular thickness and microperimetry showed a very weak or negligible correlation (rs = -0.04).In Group I of patients with outer macular diseases (21 eyes) a negligible correlation (rs = 0.04) was observed. A moderate negative correlation was found in the Group II of patients with inner retina cystic pathology (24 eyes) (rs = -0.53) and a moderate positive correlation in the Group III of patients with macular scarring (16 eyes) (rs = 0.41). The Group IV, which included 15 eyes of patients with normal fundus appearance, showed a very weak correlation (rs = 0.04).
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