Comparison of Hand-Drawn ILM and RPE Segmentation to the Retinal Segmentation Algorithm of the CirrusTM HD-OCT

Abstract

 

Purpose:

 

To compare hand drawn ILM and RPE segmentations to the retinal segmentation algorithm of the Cirrus^TM HD-OCT, a spectral domain optical coherence tomography instrument (Carl Zeiss Meditec Inc., Dublin, CA).

 

Methods:

 

A total of 163 subjects with and without retinal diseases were recruited from 4 study sites. Only one eye was used as study eye when both were eligible. Eyes were scanned with the 200x200 and 512 x 128 macular cube scans of the Cirrus^TM HD-OCT instrument. Hand-drawn segmentations on the internal limiting membrane (ILM) and retinal pigment epithelium (RPE) boundaries were performed by 7 trained experts. Differences between the hand drawn segmentations and the Cirrus^TM HD-OCT algorithm were measured.

 

Results:

 

The mean absolute differences between the segmentations classified by disease and scan type are presented in Table 1. Specific cases were analyzed to understand factors causing significant differences.

 

Conclusions:

 

The differences between the hand drawn segmentations and the instrument segmentations are smaller for higher density scans (512x128) as compared to lower density scans (200x200), and in ILM segmentations as compared to RPE segmentations. The differences appear to be influenced by various factors, such as the anatomic variations due to the retinal disease, scan type and quality, and the individual preferences of the trained experts.  

 

Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina