May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Comparison of Hand-Drawn ILM and RPE Segmentation to the Retinal Segmentation Algorithm of the CirrusTM HD-OCT
Author Affiliations & Notes
  • M. Weisbrod
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • P. Stetson
    Advanced Development Group, Carl Zeiss Meditec, Dublin, California
  • M. Wieland
    Northern California Retina and Vitreous Associates, Mountain View, California
  • N. Bressler
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • U. Schmidt-Erfurth
    Dept. of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • R. Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • G. Gregori
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • Footnotes
    Commercial Relationships  M. Weisbrod, None; P. Stetson, Carl Zeiss Meditec, E; M. Wieland, Carl Zeiss Meditec, C; N. Bressler, Carl Zeiss Meditec, F; U. Schmidt-Erfurth, Carl Zeiss Meditec, C; Novartis, C; Alcon, C; Bayer, R; R. Knighton, Carl Zeiss Meditec, F; G. Gregori, Carl Zeiss Meditec, F.
  • Footnotes
    Support  NEI Core Center grant P30 EY014801
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4240. doi:https://doi.org/
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    • Get Citation

      M. Weisbrod, P. Stetson, M. Wieland, N. Bressler, U. Schmidt-Erfurth, R. Knighton, G. Gregori; Comparison of Hand-Drawn ILM and RPE Segmentation to the Retinal Segmentation Algorithm of the CirrusTM HD-OCT. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4240. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To compare hand drawn ILM and RPE segmentations to the retinal segmentation algorithm of the CirrusTM HD-OCT, a spectral domain optical coherence tomography instrument (Carl Zeiss Meditec Inc., Dublin, CA).

 
Methods:
 

A total of 163 subjects with and without retinal diseases were recruited from 4 study sites. Only one eye was used as study eye when both were eligible. Eyes were scanned with the 200x200 and 512 x 128 macular cube scans of the CirrusTM HD-OCT instrument. Hand-drawn segmentations on the internal limiting membrane (ILM) and retinal pigment epithelium (RPE) boundaries were performed by 7 trained experts. Differences between the hand drawn segmentations and the CirrusTM HD-OCT algorithm were measured.

 
Results:
 

The mean absolute differences between the segmentations classified by disease and scan type are presented in Table 1. Specific cases were analyzed to understand factors causing significant differences.

 
Conclusions:
 

The differences between the hand drawn segmentations and the instrument segmentations are smaller for higher density scans (512x128) as compared to lower density scans (200x200), and in ILM segmentations as compared to RPE segmentations. The differences appear to be influenced by various factors, such as the anatomic variations due to the retinal disease, scan type and quality, and the individual preferences of the trained experts.  

 
Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina 
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