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R. Shah, K. Galler, F. Recchia; A Comparison Between Fluorescein Angiography and Optical Coherence Tomography Findings in Patients With Clinically Significant Macular Edema. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4245. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate a correlation between fluorescein leakage and macular thickness measurements by optical coherence tomography (OCT) in diabetic patients with clinically significant macular edema (CSME).
Records of consecutive patients who received a diagnosis of CSME by one of the authors (FMR), fluorescein angiography (FA), and OCT testing on the same day were reviewed. For each eye, digitized early-phase and late-phase FA images overlain with an ETDRS grid were compared. Leakage within the inner zone of the ETDRS grid (1500 µm of the foveal center) and within the outer zone of the ETDRS grid (between 1500 µm and 3000 µm of the foveal center) was recorded. The macular thickness map scan protocol of the OCT3 (Zeiss Inc., Dublin, CA) was used, and the calculated thickness in each of the nine standard subfields was recorded. Values of > 250 microns for central foveal thickness and > 300 microns for other subfields were considered abnormal. For each eye, zones of FA leakage were compared with the corresponding OCT subfields.
Seventy-one eyes (of which 46 eyes were treatment-naïve) of 48 patients were studied. Leakage by FA was seen in all 71 eyes. Leakage was present in the inner zone only in 2 eyes; in the outer zone only, in 2 eyes; and in both inner and outer zones, in 67 eyes. In 24 eyes (33.8 %), all OCT thickness measurements were normal. Abnormal macular thickness was seen in 47 eyes (66.2 %): in the central foveal subfield only in 4 eyes; in the inner ring only in 5 eyes; in the outer ring only in 1 eye; and in two or more of these regions in 37 eyes. The number of eyes with abnormal OCT thickness in the subfields corresponding to the areas of FA leakage are shown in the table:There were no cases in which abnormal OCT thickness was not associated with FA leakage in the corresponding anatomic region.
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