May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
3-Dimensional Visualization of the Hyaloid Face in Idiopathic Macular Hole by Spectral-Domain Optical Coherence Tomography
Author Affiliations & Notes
  • P. Gupta
    Doheny Eye Institute, University of Southern California, Los Angeles, California
  • B. J. Lujan
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • G. Gregori
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • H. W. Flynn
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • W. E. Smiddy
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • C. A. Puliafito
    Doheny Eye Institute, University of Southern California, Los Angeles, California
  • Footnotes
    Commercial Relationships  P. Gupta, None; B.J. Lujan, Carl Zeiss Meditec, F; G. Gregori, Carl Zeiss Meditec, F; H.W. Flynn, None; W.E. Smiddy, None; C.A. Puliafito, Carl Zeiss Meditec, F; Carl Zeiss Meditec, C; Carl Zeiss Meditec, R.
  • Footnotes
    Support  NIH Core Center Grant P30 EY014801; Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4249. doi:https://doi.org/
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      P. Gupta, B. J. Lujan, G. Gregori, H. W. Flynn, W. E. Smiddy, C. A. Puliafito; 3-Dimensional Visualization of the Hyaloid Face in Idiopathic Macular Hole by Spectral-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4249. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

While the exact pathogenesis of idiopathic macular holes remainsunclear, the interaction of the posterior hyaloid face withthe retina as seen by optical coherence tomography (OCT) suggeststhe vitreous is an active component. Spectral-domain OCT (SD-OCT)provides high resolution, volumetric data in which the vitreo-retinalinterface of patients with macular holes can be modeled threedimensionally.

 
Methods:
 

4 eyes with full-thickness idiopathic macular holes were scannedusing SD-OCT. A 6mm x 6mm area was acquired using a raster scanprotocol consisting of 512x128 axial scans. The posterior hyaloidface was manually demarcated on each of the 128 slices and wasthen rendered as a three-dimensional model above the plane ofthe internal limiting membrane (ILM).

 
Results:
 

Three-dimensional images were successfully generated in eachof the eyes, showing the interface between the hyaloid and theILM. Each of these models showed the hyaloid face to be touchingthe ILM adjacent to the fovea, with surrounding separation ofthe vitreous and retina. Three-dimensional ripples were visualizedon the hyaloid that were not uniform in all directions, thussuggesting differing tensions along the vitreo-retinal interface.

 
Conclusions:
 

SD-OCT can evaluate the interaction between the retina and theposterior hyaloid three-dimensionally. Visualization and futurequantitation of this anatomy may provide a greater understandingof the role that the vitreous plays in macular hole formationand progression.  

 

 
Keywords: imaging/image analysis: clinical • macular holes • vitreous 
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