May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
Repeatability Of Retinal Thickness Measurements Using CirrusTm HD-OCT
Author Affiliations & Notes
  • M. A. Chang
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • M. Durbin
    Carl Zeiss Meditec, Dublin, California
  • M. Wieland
    Northern California Retina Vitreous Associates, Mountain View, California
  • U. Schmidt-Erfurth
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • G. Gregori
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • N. M. Bressler
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  M.A. Chang, Carl Zeiss Meditec, F; M. Durbin, Carl Zeiss Meditec, E; M. Wieland, Carl Zeiss Meditec, C; U. Schmidt-Erfurth, Carl Zeiss Meditec, C; G. Gregori, Carl Zeiss Meditec, F; N.M. Bressler, Carl Zeiss Meditec, F.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4253. doi:
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      M. A. Chang, M. Durbin, M. Wieland, U. Schmidt-Erfurth, G. Gregori, N. M. Bressler; Repeatability Of Retinal Thickness Measurements Using CirrusTm HD-OCT. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4253. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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To determine the repeatability of retinal thickness measurements using Cirrus TM HD-OCT, a spectral domain optical coherence tomography instrument (Carl Zeiss Meditec, Dublin, CA).


A total of 227 subjects were recruited from 4 sites with various retinal pathologies. Only one eye was chosen as the study eye when both were eligible. Two (2) scans were acquired during a single visit with the CirrusTM HD-OCT using the same scanning protocol. Retinal thicknesses in all subfields was calculated. Analysis of variance was performed for each pathology subgroup, and repeatability standard deviation (SD) was determined by taking the square root of the random variance component. Assuming a normal distribution of random errors, the repeatability 95% limits are expected to be 2.77*SD.


A few scans were rejected due to algorithm failures, poor placement of scan, or poor quality (5-10%). The repeatability SD of the remaining scans varied by pathology (see Table 1).


The repeatability of measurements for retinal thicknesses with CirrusTM HD-OCT is excellent for normals. For cases with pathology, it also appears more than adequate for clinical practice in this study. Improvements in repeatability for low vision pathologies likely will be seen when registration between scans is performed.  

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 

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