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M. Ritter, J. A. Elledge, M. K. W. Webster, C. Simader, G. G. Deak, M. Bolz, K. Polak, B. A. Blodi, U. M. Schmidt-Erfurth; Evaluation of OCT Images in Age-Related Macular Degeneration: A Reproducibility Study of Two Independent Reading Centers. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4255.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the reproducibility among readers of the Vienna Reading Center (VRC) and the Reading Center of the University of Wisconsin-Madison (UW-FPRC) for optical coherence tomography (OCT) images in age-related macular degeneration (AMD).
Fast macular thickness scans and 6 mm cross hair scans were obtained from 100 eyes with all forms of AMD using a Stratus OCT. Consensus readings were performed by 2 certified OCT readers of each Reading Center using their grading protocol developed for AMD clinical trials. Common variables of both grading protocols, such as presence of cystoid spaces, subretinal fluid, vitreomacular traction and retinal pigment epithelial detachment were compared using kappa statistics. In addition, the intraclass correlation coefficient (ICC) was calculated for central retinal thickness (CRT) values partially remeasured manually in the presence of align errors.
There was a high level of agreement between the consensus readings of the two Reading Centers in this series of AMD cases with an overall kappa value of 0.76. The reproducibility was strongly dependent on the parameter measured with a kappa value of 0.82 for the presence of cystoid spaces, 0.76 for the presence of subretinal fluid and 0.795 for the presence of vitreomacular traction. The lowest reproducibility was found for the presence of retinal pigment epithelial detachment with a kappa value of 0.675. The CRT was remeasured in 31 out of 100 scans on both sites with an ICC of 0.85.
OCT scan data are of high importance to monitor treatment efficacy in AMD clinical trials. For comparison of results obtained by different Reading Centers the inter-Reading Center reproducibility is essential. Although the reproducibility is generally high, the reliability depends on the selected morphological parameters.
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