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P. M. Brennen, T. R. Friberg, L. Kagemann, H. Ishikawa, J. S. Schuman; Clinical Relevance of C-Mode Depiction of 3D Spectral Domain Optical Coherence Tomography Data in Retinal Disease: Initial Impressions. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4269.
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To demonstrate the clinical relevance of contour modeling C-mode in retinal disease using three-dimensional spectral domain optical coherence tomography (3D SDOCT).
In an observational case series study, 21 patients previously diagnosed with age-related macular degeneration, diabetic retinopathy, unexplained visual loss, retinal vein occlusion, macular hole, macular pucker, or retinitis pigmentosa (RP) were scanned with SDOCT, using primarily the Cirrus OCT (Carl Zeiss Meditec, Inc., Dublin, CA). 3D SDOCT data (200x200x1024 samples in a 6x6x2 mm volume centered on the fovea) were obtained from both eyes. The reflectivity values of the region of interest were sampled within a variable thickness "slab" along a manually modeled 3D contour using software of our own design. The output images resembled conventional C-mode images aligned to the ILM or RPE, placing the tissues of interest into a single plane.
In eight patients with age-related macular degeneration, C-mode images were useful in six to estimate drusen volume. In two patients, the presence of disciform scar made identification of drusen difficult. In six patients with diabetic macular edema or edema secondary to retinal vein occlusion, C-mode images were useful in all but one patient to estimate the area (extent) of the edema. In one patient, minimal cystic changes were poorly rendered. In four RP patients, C-mode images were less useful, perhaps due to retinal thinning, but in one patient with RP and macular edema and one patient with RP and a macular cyst, C-mode images were useful in delimiting the extent of edema and the presence of vitreo-macular traction, respectively. Of three patients with macular hole or pucker, C-mode images were useful in all patients in amplifying vitreo-macular traction patterns.
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