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V. V. Virasch, M. W. MacCumber, S. Mudvari; Ultra-Widefield Imaging in CMV Retinitis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4275.
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To compare the Optomap imaging system, a novel ultra-widefieldimaging system to the standard nine-field fundus photographysystem for the diagnosis and management of cytomegalovirus retinitispatients.
Subjects who are currently enrolled in the Rush University MedicalCenter arm of the Longitudinal Study of Ocular Complicationsof AIDS (LSOCA) will be recruited for participation in thistrial. In addition to the retinal examinations and conventionalfundus photography (which are obtained every three months insubjects with major ocular complications), the study proposesto obtain a fundus photograph using the Optomap Ultra-WidefieldFundus Camera system at the time of each visit. Subjects willbe enrolled in the study for a total of 12 months. At the endof the subject’s participation, four Optomap images willbe available for comparison.
13 eyes of 8 patients were analyzed. We found that wide-fieldimaging imaged 29.1% greater total retinal areas than standardfundus photography. It also imaged 22.1% greater CMV retinitislesion areas than standard fundus photography. When posteriorpole lesions are eliminated from the analysis, wide-field imagingcaptured 41.8% greater peripheral CMV retinitis lesion areasthan standard nine-field fundus photography.
Our study suggests that the ultra wide-field imaging modalitycaptures a greater area of total retina as well as peripheralCMV retinitis lesions compared to standard nine-field fundusphotography. For posterior pole CMV retinitis lesions, the twomodalities were comparable.
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