May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Limited Topography-Guided Surface Ablation (TGSA) Followed by Stabilization With Collagen Cross-Linking With Uv Irradiation & Riboflavin (UVACCL) for Keratoconus (KC)
M. Ewald; J. Kanellopoulos
Author Affiliations & Notes
  • M. Ewald
    Ophthalmology/NYU/Manhat Eye Ear Throat, NYU/Manhattan Ear Eye and Throat Hosp, New York, New York
  • J. Kanellopoulos
    Ophthalmology/NYU/Manhat Eye Ear Throat, NYU/MEETH/Laservision Institute, New York, New York
  • Footnotes
    Commercial Relationships  M. Ewald, None; J. Kanellopoulos, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4338. doi:
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      M. Ewald, J. Kanellopoulos; Limited Topography-Guided Surface Ablation (TGSA) Followed by Stabilization With Collagen Cross-Linking With Uv Irradiation & Riboflavin (UVACCL) for Keratoconus (KC). Invest. Ophthalmol. Vis. Sci. 2008;49(13):4338.

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Abstract

Purpose: : To investigate the safety & efficacy of TGSA and UVACCL as one procedure for keratoconus (KC) visual rehabilitation.

Methods: : We evaluated limited topography-guided surface ablation (TGSA) with the Wavelight device, followed by UV-irradiation and riboflavin collagen crosslinking (UVACCL) in 45 eyes with KC. Refraction, uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BSCVA), pentacam topography (PT), endothelial cell count (ECC) and pachymetry (PC) were evaluated pre-treatment and post-treatment, for an average of 19 months (ranging from 14-21).

Results: : Keratoconus progression stabilized after TGSA and UVACCL treatment, with the following results: Average UCVA improved from 20/400 to 20/100.Average BSCVA improved from 20/100 to 20/30.On average, there was a reduction in the refractive correction sphericalequivalent of 6.4 D per eye.ECC demonstrated no statistical change.The PT mean keratometry reduced from 53 to 44.PC was reduced from 420 to 380 microns.1 eye needed to undergo penetrating keratoplasty (PK)despite TGSA and UVACCL treatment.

Conclusions: : TGSA & UVACCL may offer effective visual rehabilitation for KC, and it may delay or eliminate the need for PK. Long-term results with greater follow-up are necessary to confirm the stability and safety of UVACCL in controlling and stabilizing KC.

Keywords: keratoconus • cornea: stroma and keratocytes • topography 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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