May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
External Ophthalmic Arterial Re-Anastomosis to External Carotid System After Swine Optic Nerve Transection
Author Affiliations & Notes
  • J. Kim
    Ophthalmology and Visual Sciences, Illinois Eye Institute, University of Illinois at Chicago, Chicago, Illinois
  • C.-W. Wu
    Ophthalmology and Visual Sciences, Illinois Eye Institute, University of Illinois at Chicago, Chicago, Illinois
  • W. Mahran
    Ophthalmology and Visual Sciences, Illinois Eye Institute, University of Illinois at Chicago, Chicago, Illinois
  • T. Kojima
    Ophthalmology and Visual Sciences, Illinois Eye Institute, University of Illinois at Chicago, Chicago, Illinois
  • J.-H. Chang
    Ophthalmology and Visual Sciences, Illinois Eye Institute, University of Illinois at Chicago, Chicago, Illinois
  • H. Qian
    Ophthalmology and Visual Sciences, Illinois Eye Institute, University of Illinois at Chicago, Chicago, Illinois
  • D. T. Azar
    Ophthalmology and Visual Sciences, Illinois Eye Institute, University of Illinois at Chicago, Chicago, Illinois
  • Footnotes
    Commercial Relationships  J. Kim, None; C. Wu, None; W. Mahran, None; T. Kojima, None; J. Chang, None; H. Qian, None; D.T. Azar, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4366. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. Kim, C.-W. Wu, W. Mahran, T. Kojima, J.-H. Chang, H. Qian, D. T. Azar; External Ophthalmic Arterial Re-Anastomosis to External Carotid System After Swine Optic Nerve Transection. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4366. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To study the feasibility of ocular reperfusion after vascular anastomosis in swine optic nerve transection.

Methods: : Experiment I (ex vivo perfusion). Under the general anesthesia, baseline ERG and fluorescein angiography was performed. Swine eye was enucleated or exenterated and perfused ex vivo using a specially-designed pulsatile Krebs perfusate. Ocular viability was evaluated using ERG with scotopic conditions. Experiment II (in vivo perfusion). Under the general anesthesia, external maxillary artery was secured in facial area. Its proximal end was cut-down and anastomosed with heparin-filled specially-designed silastic tube. Swine external ophthalmic artery was explored between inferior and lateral extraocular muscles (EOM) and the distal end of external ophthalmic artery was cut-down and anastomosed with silastic tube. Both silastic tubes from external ophthalmic artery and external maxillary artery was connected so as external maxillary artery supplied external ophthalmic artery. Optic nerve was posteriorly transected near orbital apex. Eyeball was exenterated or enucleated after all EOMs were detached.

Results: : Scotopic ERG was maintained until two hours after ex vivo reperfusion. Ophthalmic arterial re-anastomosis to external maxillary artery was successfully performed in porcine eyes.

Conclusions: : ERG was maintained two hours after ocular reperfusion of swine eyes ex vivo not in vivo. As compared to enucleated eye, surgical feasibility of external ophthalmic arterial re-anastomosis to external carotid system was greater in exenterated eye.

Keywords: optic nerve • optic flow • visual search 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×