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S. Honda, T. Nagai, A. Negi; Anti-Angiogenic Effects of Integrin vβ3 Specific Antagonist BS-1417 on Laser-Induced Choroidal Neovascularization in Mice. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4409.
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To evaluate the anti-angiogenic effects of integrin αVβ3 specific antagonist BS-1417 on laser-induced choroidal neovascularization (CNV) in mice.
Male C57BL/6 mice were treated with daily intraperitoneal injections of BS-1417 or saline starting at the onset (day 0) of experiments. CNV was induced by laser photocoagulation the next day and fluorescein angiograms (FA) were performed on experimental day 7. Histological and immunohistochemical examinations were performed with consecutive cryosections.
BS-1417 significantly decreased the area of dye leakage determined by FA (40% of control, p=0.0008). In histological findings, BS-1417 significantly suppressed the size of laser-induced CNV. Immunoreactivities for VEGF and integrin αV were remarkably attenuated with BS-1417 compared to control.
The integrin αVβ3 may play a key role in the induction of laser-induced CNV. The antagonists for integrin αVβ3 may have therapeutic effects in CNV associated diseases such as age-related macular degenerations.
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