May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
Effects of Phenylephrine 5% on Accommodative Response and Ocular Wavefront Aberrations Variations
Author Affiliations & Notes
  • J.-J. Gicquel
    Ophthalmology, Jean Bernard University Hospital, Poitiers, France
  • J.-L. Nguyen Khoa
    Ophthalmology, Hopital Foch, Suresne, France
  • F. Harms
    Imagine Eyes, Orsay, France
  • N. Lopez-Gil
    Physics, Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain
  • R. Legras
    Laboratoire Aime Cotton, Universite d'Orsay, Orsay, France
  • D. Lebuisson
    Ophthalmology, Hopital Foch, Suresne, France
  • J.-F. Le Gargasson
    Laboratoire de Biophysique, Université Paris VII, Paris, France
  • Footnotes
    Commercial Relationships  J. Gicquel, None; J. Nguyen Khoa, None; F. Harms, F.Harms is employed by Imagine Eyes Inc who is the manufacturer of the IRX3 Wavefront Aberrometer used in this study, I; N. Lopez-Gil, None; R. Legras, None; D. Lebuisson, None; J. Le Gargasson, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4558. doi:
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      J.-J. Gicquel, J.-L. Nguyen Khoa, F. Harms, N. Lopez-Gil, R. Legras, D. Lebuisson, J.-F. Le Gargasson; Effects of Phenylephrine 5% on Accommodative Response and Ocular Wavefront Aberrations Variations. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4558.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To study the effects of phenylephrine 5% topical administration on accommodative response and optical aberrations variation in young healthy subjects.

Methods: : The research followed the tenets of the Declaration of Helsinki . 28 eyes from 14 volunteers with spherical equivalent defocus error between -2D and +1D, no eye disease history and between 20 to 25 years of age, underwent wavefront measurements with an Imagine Eyes® IRX3 Shack-Hartmann wavefront aberrometer which included a movable accommodative target. Wavefront data was acquired while applying 6 different increasing accommodative stimuli, from 0 D to 5 D by steps of 1 D, before and after pupil dilation with Phenylephrine 5%.

Results: : The dilation using Phenylephrine 5% was found to larger lag errors in the accommodative response of about half of the subjects. The total RMS amount of aberrations above defocus remained stable during accommodation with and without dilation. Spherical aberration was positive in average in the non accommodated eye and changed toward negative values with increasing accommodation (p<0.05). Cylinder axis came closer to 90° as accommodation increased (p<0.05). Although vertical coma did not significantly vary with accommodation, horizontal coma increased significantly with accommodation (p<0.05). These changes in aberrations with increasing accommodation were similar on average in both pupil conditions.

Conclusions: : Phenylephrine 5% modifies the accommodative focus response of a significant proportion of young adult eyes. Wavefront aberrations above defocus undergo similar variations in both natural and dilated pupil conditions. However the total RMS error of aberrations above defocus remains relatively constant when the eye accommodates.

Keywords: accomodation • aberrations • optical properties 

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