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U. K. Nair, A. Bui, R. Roe, A. D. Fu, J. M. Jumper, R. N. Johnson, H. R. McDonald, E. T. Cunningham, Jr.; Blood Pressure Measurements Following Intravitreal Ranibizumab. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4577.
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To evaluate the effect of intravitreal Ranibizumab on blood pressure in patients with neovascular age-related macular degeneration (AMD).
Retrospective chart review was conducted for consecutive patients (n=71) who received intravitreal Ranibizumab to treat neovascular AMD had blood pressure measured prior to intravitreal injection and at monthly follow up visits.
Follow up ranged from 0 to 10 months, with a mean of 3.4 and a median of 4 months. 63% of patients had a history of systemic hypertension and 4% had a history of stroke prior to receiving Ranibizumab. Average pre-injection systolic, diastolic, and mean arterial blood pressures (MAP) were 132, 73.30, and 92.88 respectively. Average post-injection systolic, diastolic and MAP at one month were 131.80, 71, and 94.95. One patient (1.4%) had a stroke between her second and third visits. Another patient was found to have a pigment epithelial tear. None of these patients experienced a change in blood pressure following their first injection. No other ocular or systemic adverse events were noted.
Ranibizumab does not appear to affect systemic blood pressure in the short term.
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