May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Retrobulbar Hemodynamics and Intraocular Pressure in Primary Open Angle Glaucoma Patients
Author Affiliations & Notes
  • N. S. Kheradiya
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • A. Harris
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • I. BenZion
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • B. DeStefano
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • D. WuDunn
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • H. J. Garzozi
    Department of Ophthalmology, Bnai Zion Faculty of Medicine, Technion, Haifa, Israel
  • L. McCranor
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • C. W. Yung
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Footnotes
    Commercial Relationships  N.S. Kheradiya, None; A. Harris, None; I. BenZion, None; B. DeStefano, None; D. WuDunn, None; H.J. Garzozi, None; L. McCranor, None; C.W. Yung, None.
  • Footnotes
    Support  Supported in part by an unrestricted research grant from Research to Prevent Blindness, New York, NY
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4606. doi:https://doi.org/
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      N. S. Kheradiya, A. Harris, I. BenZion, B. DeStefano, D. WuDunn, H. J. Garzozi, L. McCranor, C. W. Yung; Retrobulbar Hemodynamics and Intraocular Pressure in Primary Open Angle Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4606. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the relationship between retrobulbar blood flow velocities measured with color Doppler imaging (CDI) and intraocular pressure (IOP) in primary open angle glaucoma (POAG) patients

Methods: : A retrospective analysis of 5 consecutive prospective POAG studies (69 POAG patients) carried out at the Indiana University School of Medicine was performed. Each patient was on timolol for one month prior to the study visit to minimize variations due to differing medications. For every patient, IOP was assessed as an average of three separate measurements using Goldman applanation tonometry. Retrobulbar blood flow velocities were assessed in the ophthalmic, central retinal, and short nasal and temporal posterior ciliary arteries using CDI (Siemens Quantum 2000). Peak systolic velocity, end diastolic velocity, and calculated resistive index were determined for each vessel and statistically compared to the IOP for each patient. The strength of the linear association among IOP and CDI parameters was assessed using Pearson Correlation Coefficients.

Results: : End diastolic velocity in the central retinal and ophthalmic arteries were significantly correlated with IOP (r=0.31, p=0.008, r=0.3, p=0.01, respectively) in glaucoma patients. The calculated vascular resistance in the ophthalmic artery was also significantly correlated (inversely) to IOP (r=-0.28, p=0.02). No significant correlations; however, were observed between IOP and any measure of short posterior ciliary artery blood flow in this cohort of glaucoma patients.

Conclusions: : The lack of correlation between the short posterior ciliary arteries and IOP in glaucoma patients may indicate impaired hemodynamic autoregulation in the blood vessels supplying the optic nerve head. In this POAG cohort, the inability of blood vessels supplying the pre-laminar, laminar and retinal microcirculation to respond to fluctuations in IOP may contribute to optic nerve head damage seen in glaucomatous optic neuropathy.

Keywords: intraocular pressure • blood supply • optic nerve 
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