May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Circle versus Raster Scans Using Cirrus HD-OCT - Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements
Author Affiliations & Notes
  • V. Jurisic
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
    Dept of BioE, Swanson Sch of Engin, Univ of Pitt, Pittsburgh, Pennsylvania
  • L. Kagemann
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
    Dept of BioE, Swanson Sch of Engin, Univ of Pitt, Pittsburgh, Pennsylvania
  • M. L. Gabriele
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
    Dept of BioE, Swanson Sch of Engin, Univ of Pitt, Pittsburgh, Pennsylvania
  • J. Xu
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
  • J. Kim
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
  • J. G. Fujimoto
    Dept of Elec Engin and Comp Sci and Res Lab of Electronics, Massachusetts Inst of Techn, Cambridge, Massachusetts
  • J. S. Schuman
    UPMC Eye Cent, Eye and Ear Inst, Ophthal Vis Sci Res Cent, Dept. of Ophthal., Univ of Pittsburgh Sch Med, Pittsburgh, Pennsylvania
    Dept of BioE, Swanson Sch of Engin, Univ of Pitt, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  V. Jurisic, None; G. Wollstein, Carl Zess Meditec, Inc; Optovue, F; R.A. Bilonick, None; H. Ishikawa, None; L. Kagemann, None; M.L. Gabriele, None; J. Xu, None; J. Kim, None; J.G. Fujimoto, Optovue, F; Carl Zeiss Meditec. Inc., P; J.S. Schuman, Alcon; Allergan; Carl Zeiss Meditec, Inc; Merck; Heidelberg Engineering; Optovue, F; Carl Zeiss Meditec. Inc., P; Alcon; Allergan; Carl Zeiss Meditec, Inc; Merck; Heidelberg Engineering; Optovue, R.
  • Footnotes
    Support  NIH R01-EY013178-8, R01-EY11289-22, P30-EY008098, AFOSR FA9550-040-1-001, NSF BES-0522845; Eye and Ear Foundation (Pittsburgh,PA); Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4623. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      V. Jurisic, G. Wollstein, R. A. Bilonick, H. Ishikawa, L. Kagemann, M. L. Gabriele, J. Xu, J. Kim, J. G. Fujimoto, J. S. Schuman; Circle versus Raster Scans Using Cirrus HD-OCT - Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4623. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

Spectral domain optical coherence tomography (SDOCT) provides high-speed, high-resolution images and permits the acquisition of three-dimensional (3D) raster scans. The purpose of this study was to compare the reproducibility of circumpapillary retinal nerve fiber layer (RNFL) thickness measurements obtained from circle scans with circular measurements extracted from raster scans.

 
Methods:
 

Fifty healthy subjects (100 eyes) were scanned with SDOCT Cirrus HD-OCT: Carl Zeiss Meditec, Dublin, CA. All subjects had ≥ 3 circumpapillary scans centered at the optic nerve head (ONH) and ≥ 3 raster scans of the ONH region. RNFL thickness was automatically extracted from the 3D data along a circle with a diameter identical to that of the circle scan.Linear mixed effects models were used to determine reproducibility (presented as standard deviation (SD)) for average, quadrant and clock-hour RNFL thickness.

 
Results:
 

RNFL measurements from the raster scan were statistically significantly thinner than those obtained from the circle scan for all tested parameters. The table summarizes the mean and SD with their 95% confidence intervals for average and quadrant parameters. Raster derived clock-hour measurements had a smaller SD in the range of 45.0%-67.8% (clock-hours 8 and 10, respectively) as compared to circle scan SD. The differences in SD for average and all sectoral measurements were statistically significant.

 
Conclusions:
 

Circumpapillary RNFL measurements extracted from raster scans of the ONH region had significantly better reproducibility than actual physical circumpapillary scans. While the physical circumpapillary scan is prone to inadvertent eye motion, extracting measurements from the raster scan permits a more consistent sampling of the tissue at an identical location from scan to scan.  

 
Clinical Trial:
 

www.clinicaltrials.gov NCT 00343746

 
Keywords: imaging/image analysis: clinical • nerve fiber layer • image processing 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×