May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Symmetry Between the Right and Left Eyes of the Normal Retinal Nerve Fiber Layer as Measured by Stratus OCT
Author Affiliations & Notes
  • D. L. Budenz
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • N. Sekhon
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • A. Moraczewski
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • G. Gregori
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • W. J. Feuer
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • D. R. Anderson
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • Footnotes
    Commercial Relationships  D.L. Budenz, Carl Zeiss Meditec, F; N. Sekhon, Carl Zeiss Meditec, F; A. Moraczewski, Carl Zeiss Meditec, F; G. Gregori, Carl Zeiss Meditec, F; W.J. Feuer, Carl Zeiss Meditec, F; D.R. Anderson, Carl Zeiss Meditec, F.
  • Footnotes
    Support  NIH center grant P30 EY014801, awarded by the National Eye Institute, Bethesda, MD; unrestricted grant from Research to Prevent Blindness, N.Y. N.Y. Equipment on loan from Carl Zeiss Meditec
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4633. doi:https://doi.org/
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      D. L. Budenz, N. Sekhon, A. Moraczewski, G. Gregori, W. J. Feuer, D. R. Anderson; Symmetry Between the Right and Left Eyes of the Normal Retinal Nerve Fiber Layer as Measured by Stratus OCT. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4633. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the limits of the normal amount of interocular asymmetry in retinal nerve fiber layer (RNFL) thickness measurements obtained with StratusTM Ocular Coherence Tomography (OCT).

Methods: : Peripapillary Standard and Fast RNFL scans performed by the StratusTMOCT with nominal diameter of 3.46 mm centered on the optic disc were performed on both eyes of 108 normal subjects.

Results: : The mean +/- standard deviation of age of the subjects was 46.0 years (standard deviation 15.0, range 20 - 82). The 95th percentile for interocular difference was 10.1µm for Standard scan measurements and 10.5 µm for Fast scan measurements. Mean RNFL thickness correlated extremely well between the two eyes of subjects, with intraclass correlation coefficients (ICC) of 0.89 for both algorithms. ICCs were less strong and variability was greater for quadrant and clock-hour thicknesses.

Conclusions: : Mean RNFL thickness between the two eyes of normal individuals rarely differ by more than 10.1 - 10.5 µm, depending on what scan algorithm of the StratusTM is used. Differences beyond this level suggest statistically abnormal asymmetry and may be suspicious for early glaucomatous optic neuropathy.

Keywords: nerve fiber layer • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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