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W. J. Feuer, D. L. Budenz, D. R. Anderson; Differential Rates of Non-Glaucomatous Age-Related Retinal Nerve Fiber Layer Thinning Around the Optic Disc. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4634. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate whether normal age related nerve fiber layer (RNFL) thinning occurs at equal rates around the disc.
Peripapillary fast RNFL scans performed by the StratusTM OCT with nominal diameter of 3.46 mm centered on the optic disc were performed on both eyes of normal subjects over a wide age range. Following selection of one study eye per participant for analysis, clock hour and quadrant specific rates of RNFL thinning with age were calculated and compared.
The 108 study participants ranged in age from 20 to 82 years with mean (SD) 46 (15) and had a mean (SD) average RNFL thickness of 104.7 (10.8) microns. Rates of thinning per year of age ranged from -0.51 (p=0.005, r2=0.07) at clock hour 12 to +0.11 (p=.53, r2=0.00) at clock hour 6. Similarly the rate of thinning per year in the superior quadrant was -0.49 (p<0.001, r2=0.14) and in the inferior quadrant was -0.03 (p=0.77,r2=0.00). The slopes of thinning superiorly and inferiorly were highly significantly different (p=0.001).
Age related normal RNFL thinning does not occur at equal rates around the disc and is more rapid superiorly than inferiorly.
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