May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Differential Rates of Non-Glaucomatous Age-Related Retinal Nerve Fiber Layer Thinning Around the Optic Disc
Author Affiliations & Notes
  • W. J. Feuer
    Bascom Palmer, Miami, Florida
    Biostatistics,
  • D. L. Budenz
    Bascom Palmer, Miami, Florida
    Biostatistics,
  • D. R. Anderson
    Bascom Palmer, Miami, Florida
  • Footnotes
    Commercial Relationships  W.J. Feuer, None; D.L. Budenz, Zeiss Meditec, F; D.R. Anderson, Carl Zeiss Meditec, C.
  • Footnotes
    Support  EY014801, Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4634. doi:
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      W. J. Feuer, D. L. Budenz, D. R. Anderson; Differential Rates of Non-Glaucomatous Age-Related Retinal Nerve Fiber Layer Thinning Around the Optic Disc. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4634.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate whether normal age related nerve fiber layer (RNFL) thinning occurs at equal rates around the disc.

Methods: : Peripapillary fast RNFL scans performed by the StratusTM OCT with nominal diameter of 3.46 mm centered on the optic disc were performed on both eyes of normal subjects over a wide age range. Following selection of one study eye per participant for analysis, clock hour and quadrant specific rates of RNFL thinning with age were calculated and compared.

Results: : The 108 study participants ranged in age from 20 to 82 years with mean (SD) 46 (15) and had a mean (SD) average RNFL thickness of 104.7 (10.8) microns. Rates of thinning per year of age ranged from -0.51 (p=0.005, r2=0.07) at clock hour 12 to +0.11 (p=.53, r2=0.00) at clock hour 6. Similarly the rate of thinning per year in the superior quadrant was -0.49 (p<0.001, r2=0.14) and in the inferior quadrant was -0.03 (p=0.77,r2=0.00). The slopes of thinning superiorly and inferiorly were highly significantly different (p=0.001).

Conclusions: : Age related normal RNFL thinning does not occur at equal rates around the disc and is more rapid superiorly than inferiorly.

Keywords: nerve fiber layer • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • aging 
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