May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
The Effects of Age, Optic Disc Size, and Signal Strength on Fourier-Domain Optical Coherence Tomography Measurements of the Nerve Fiber Layer, Optic Disc, and Ganglion Cell Complex
Author Affiliations & Notes
  • M. J. Sinai
    Clinical Affairs, Optovue, Inc, Fremont, California
  • D. F. Garway-Heath
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
  • D. Greenfield
    Ophthalmology, Bascom Palmer Eye Institute, Palm Beach Gardens, Florida
  • M. Fingeret
    VA NY Health Care System, New York, New York
  • R. Varma
    Ophthalmology, Doheny Eye Institute, Los Angeles, California
  • J. Liebmann
    Ophthalmology, Manhattan Eye and Ear Throat Hospital, New York, New York
  • J. S. Schuman
    Ophthalmology and Visual Science Research Center, Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • D. Huang
    Ophthalmology, Doheny Eye Institute, Los Angeles, California
  • Optovue Normative Database Study Group
    Clinical Affairs, Optovue, Inc, Fremont, California
  • Footnotes
    Commercial Relationships  M.J. Sinai, Optovue, E; D.F. Garway-Heath, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Optovue, F; Carl Zeiss Meditec, C; Carl Zeiss Meditec, R; D. Greenfield, None; M. Fingeret, None; R. Varma, Optovue, F; J. Liebmann, None; J.S. Schuman, Carl Zeiss Meditec, P; Alcon, R; Optovue, R; Optovue, F; Heidelberg Engineering, F; Carl Zeiss Meditec, F; Merck, F; Allergan, F; Alcon, F; Allergan, R; Carl Zeiss Meditec, R; Heidelberg Engineering, R; Merck, R; D. Huang, Optovue, F; Optovue, C; Carl Zeiss Meditec, C; Optovue, P; Carl Zeiss Meditec, P.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4636. doi:https://doi.org/
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      M. J. Sinai, D. F. Garway-Heath, D. Greenfield, M. Fingeret, R. Varma, J. Liebmann, J. S. Schuman, D. Huang, Optovue Normative Database Study Group; The Effects of Age, Optic Disc Size, and Signal Strength on Fourier-Domain Optical Coherence Tomography Measurements of the Nerve Fiber Layer, Optic Disc, and Ganglion Cell Complex. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4636. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine the correlation of patient and scan variables with peripapillary retinal nerve fiber layer (RNFL), optic disc, and macular ganglion cell complex (GCC) values in healthy eyes.

 
Methods:
 

248 healthy eyes from 8 clinics were enrolled. All participants underwent a full eye examination, standard achromatic perimetry (SITA- standard 24-2) and scanning with the RTVue, a Fourier-domain optical coherence tomography (FD-OCT device (Optovue, Inc.). All participants had normal visual fields (GHT within normal limits and PSD > 5%) and intraocular pressure < 22 mm Hg.

 
Results:
 

Descriptive statistics for the variables (mean +/- standard deviation) are shown in the table below.VCDR=vertical cup/disc ratio; SD=standard deviation; Avg = average; Sup=superior; Inf=inferior.Significant correlations were found between age and Avg RNFL, Superior ppNFL, Inf RNFL, and Avg GCC thickness values (p<0.05 for all, one-tailed test). Signal strength was significantly correlated with age, but no other parameter. Significant correlations were also found between optic disc size and VCDR (p<0.005), cup area (p<0.001), rim area (p<0.001), Avg RNFL (p<0.005), Sup RNFL (p<0.005), and Inf RNFL (P<0.025).  

 
Conclusions:
 

Significant effects for age and optic disc size were found for many RNFL, optic disc, and GCC parameters with a FD-OCT device. Anatomical measurements were not affected by signal strength.

 
Keywords: imaging/image analysis: clinical • optic nerve • ganglion cells 
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