May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
The Effect of Axial Scan Location on Signal Quality and Thickness Measurements Obtained With Spectral Domain Optical Coherence Tomography
Author Affiliations & Notes
  • M. L. Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • L. Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • J. Xu
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. S. Kim
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • V. Jurisic
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. G. Fujimoto
    Dept. of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  M.L. Gabriele, None; H. Ishikawa, None; R.A. Bilonick, None; G. Wollstein, Carl Zeiss Meditec, Inc; Optovue, F; L. Kagemann, None; J. Xu, None; J.S. Kim, None; V. Jurisic, None; J.G. Fujimoto, Optovue, F; Carl Zeiss Meditec, Inc, P; J.S. Schuman, Alcon; Allergan; Carl Zeiss Meditec, Inc.; Merck; Heidelberg Engineering; Optovue, F; Carl ZeissMeditec, Inc., P; Alcon; Allergan; Carl Zeiss Meditec, Inc.; Merck; Heidelberg Engineering; Optovue, R.
  • Footnotes
    Support  NIH R01-EY013178-8, R01-EY11289-22, P30-EY008098; AFOSR FA9550-040-1-0011; NSF BES-0522845; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4637. doi:
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    • Get Citation

      M. L. Gabriele, H. Ishikawa, R. A. Bilonick, G. Wollstein, L. Kagemann, J. Xu, J. S. Kim, V. Jurisic, J. G. Fujimoto, J. S. Schuman; The Effect of Axial Scan Location on Signal Quality and Thickness Measurements Obtained With Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4637.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Spectral domain optical coherence tomography (SDOCT) signal level varies depending on the location of target tissue within a scanning window. Our goal was to test whether axial scan location (top of scanning window versus bottom) affects scan quality and thickness measurements.

Methods: : Thirteen eyes from 13 healthy subjects were imaged using SDOCT (Cirrus OCT; Carl Zeiss Meditec, Dublin, CA). A total of six Macular Cube Combo (200x200x1024 samplings in 6.0x6.0x2.0mm volume, followed by a frame of 1000 samplings in both the horizontal and vertical directions, all centered on the fovea) images were obtained for each subject, three images located at the top of the image window and three images at the bottom of the image window (order of acquisition randomized). Two signal quality parameters (Cirrus signal strength (SS) [ordinal parameter] and quality index (QI) [continuous parameter]) were obtained for all images, while retinal nerve fiber layer (RNFL) and total retinal thicknesses (TRT) were measured on the horizontal and vertical scans. Changes in quality parameters and thickness measurements were characterized using linear mixed effects modeling.

Results: : Cirrus SS was equivalent to 10 for all top images while bottom images had an average SS of 7.69 ± 0.80. QI was statistically significantly higher for images located at the scanning window top as compared to bottom (mean difference [95% confidence interval]: 18.42[17.12-19.72]). In horizontal scans, top images showed a significantly thicker RNFL (mean difference: 3.66[2.25-5.08]µm) and TRT (mean difference: 5.06[2.77-7.25]µm) as compared to bottom images. Statistically significant differences were also seen in vertical scans (RNFL thickness mean difference: 3.00[1.53-4.48]µm, TRT mean difference: 2.71[1.32-4.10]µm).

Clinical Trial: : www.clinicaltrials.gov 00343746

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 
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