May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Glaucoma Diagnosis by Mapping Peripapillary Nerve Fiber Layer Thickness With Fourier Domain Optical Coherence Tomography
Author Affiliations & Notes
  • O. Tan
    Doheny Eye Institute and Dept. Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • A. T. Lu
    Doheny Eye Institute and Dept. Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • V. Chopra
    Doheny Eye Institute and Dept. Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • R. Varma
    Doheny Eye Institute and Dept. Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • H. Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • D. Huang
    Doheny Eye Institute and Dept. Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • Footnotes
    Commercial Relationships  O. Tan, Optovue, Inc, F; Optovue, Inc, P; A.T. Lu, None; V. Chopra, None; R. Varma, Optovue, Inc, F; H. Ishikawa, None; G. Wollstein, Optovue, Inc, F; Carl Zeiss Meditec, Inc, F; J.S. Schuman, Carl Zeiss Meditec, Inc, F; Optovue, Inc, F; Heidelberg Engineering, F; Carl Zeiss Meditec, Inc, C; Merc, R; Heidelberg Engineering, R; Merck, F; Alco, F; Optovue, Inc, C; Carl Zeiss Meditec, Inc, R; Alcon, R; Allergan, F; Allergan, R; Optovue, R; D. Huang, Carl Zeiss Meditec, Inc, F; Optovue, Inc, F; Optovue, Inc, I; Optovue, Inc, C; Carl Zeiss Meditec, Inc, P; Optovue, Inc, P; Optovue, Inc, R.
  • Footnotes
    Support  NIH grants R01 EY013516, P30 EY03040, R01-EY013178-8, P30-EY008098; Research to Prevent Blindness; Optovue, Inc.;Eye and Ear Foundation (Pittsburgh, PA);
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4655. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      O. Tan, A. T. Lu, V. Chopra, R. Varma, H. Ishikawa, G. Wollstein, J. S. Schuman, D. Huang; Glaucoma Diagnosis by Mapping Peripapillary Nerve Fiber Layer Thickness With Fourier Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4655. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To evaluate the glaucoma diagnostic performance of peripapillary nerve fiber layer (ppNFL) thickness mapping using high-speed, high-resolution Fourier-domain optical coherence tomography (FD-OCT).

 
Methods:
 

Participants in the Advanced Imaging for Glaucoma (www.AIGStudy.net) were scanned using the RTVue FD-OCT system (Optovue, Inc. Fremont, CA), which performs 26,000 axial scans per second and has 5-micron depth resolution. We developed a 4-mm diameter Nerve Head Map (NHM4) scan pattern which includes 12 radial scans and 6 circular scans with diameters from 2.5 to 4 mm. We developed an automated image processing algorithm to detect the NFL boundary and map the ppNFL thickness in an annular region of 2.5-4.0 mm diameter. The results were compared with ppNFL measurements obtained from a conventional time-domain OCT system (Stratus, Carl Zeiss Meditec, Inc.) using the 3.4 mm diameter circular scan in the same eyes.

 
Results:
 

OCT scans were obtained from 113 normal (N), 74 pre-perimetric glaucoma (PPG), and 108 perimetric glaucoma (PG) eyes. The diagnostic power was assess by the area under the receiver operating curve (AROC) and the reproducibility was assessed by coefficient of variance (CV) in the Table 1. FD-OCT showed a trend toward better diagnostic accuracy and reproducibility.Table 1. Diagnostic accuracy and reproducibility of overall ppNFL thickness average  

 
Conclusions:
 

ppNFL measurement by FD-OCT provided a moderate improvement in diagnostic accuracy and reproducibility over TD-OCT. This is expected based on the sampling of more retinal locations in a shorter period of time, in addition to greater resolution.

 
Keywords: imaging/image analysis: clinical • optic nerve • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×