May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Ability of the Stratus OCT to Detect Pre-Perimetric Glaucoma in a Prospective Longitudinal Study
Author Affiliations & Notes
  • J. M. Martinez de la Casa
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
    Universidad Complutense, Madrid, Spain
  • F. A. Medeiros
    Hamilton Glaucoma Center, La Jolla, California
  • G. Vizzeri
    Hamilton Glaucoma Center, La Jolla, California
  • C. Bowd
    Hamilton Glaucoma Center, La Jolla, California
  • L. Zangwill
    Hamilton Glaucoma Center, La Jolla, California
  • R. N. Weinreb
    Hamilton Glaucoma Center, La Jolla, California
  • Footnotes
    Commercial Relationships  J.M. Martinez de la Casa, None; F.A. Medeiros, Heidelberg Engineering, F; Carl Zeiss Meditec, F; Carl Zeiss Meditec, R; G. Vizzeri, None; C. Bowd, Lace Elettronica, F; L. Zangwill, Heidelberg Engineering, F; Carl Zeiss Meditec, F; Optovue, F; R.N. Weinreb, Heidelberg Engineering, F; Carl Zeiss Meditec, F.
  • Footnotes
    Support  EY011008, Participant incentive grants in the form of glaucoma medication at no cost from Alcon Laboratories Inc, Allergan, Pfizer Inc., and SANTEN Inc.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4658. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. M. Martinez de la Casa, F. A. Medeiros, G. Vizzeri, C. Bowd, L. Zangwill, R. N. Weinreb; Ability of the Stratus OCT to Detect Pre-Perimetric Glaucoma in a Prospective Longitudinal Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4658. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To evaluate the ability of optical coherence tomography (OCT) to detect retinal nerve fiber layer (RNFL) loss in patients suspected of having glaucoma.

Methods: : The study included a cohort of 72 patients longitudinally followed as part of the Diagnostic Innovations in Glaucoma Study (DIGS). All patients were suspected of having glaucoma based on the appearance of the optic disc, but had normal standard automated perimetry visual fields at the time of imaging. Patients were classified based on history of documented stereophotographic evidence of progressive glaucomatous change in the appearance of the optic nerve occurring before the imaging session. RNFL thickness was measured in the two groups using the Fast RNFL thickness protocol of the Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA). Areas under the Receiver Operating Characteristic (ROC) curves (AUCs) were calculated for each parameter.

Results: : Twenty-nine eyes with evidence of glaucomatous progressive optic disc change during follow-up were included in the glaucoma group and 43 eyes observed untreated for an average time of 9.01 +/- 3.09 years without any evidence of progressive damage to the optic nerve were included in the control group. Statistically significant differences were found between the two groups for all the parameters evaluated with the exception of the temporal 8, 9, and 10 clock-hour sectors and the temporal sectoral RNFL thickness. The three parameters with the largest AUCs were the inferior quadrant (AUC = 0.86), the average RNFL thickness (AUC = 0.82), and the 6 o’clock hour sector (AUC = 0.82), although several other parameters showed similar results. The likelihood ratio for an outside-normal limits result (at least one quadrant outside normal limits) was 14.8.

Conclusions: : Stratus OCT is able to detect early RNFL loss in patients suspected of having glaucoma. These results suggest that OCT RNFL analysis can provide useful information for diagnosing glaucoma when this test is combined with clinical examination of the optic nerve.

Clinical Trial: : www.clinicaltrials.gov NCT00221897

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic nerve 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×