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N. Tomita, C. Shiragami, T. Masuda, H. Nomoto, H. Yamaji, T. Miyoshi, F. Shiraga; Fundus Autofluorescence Before and After Vitrectomy in Eyes With Idiopathic Macular Holes. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4676.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the fundus-autofluorescence imaging before and after vitrectomy in eyes with idiopathic macular holes.
Sixteen consecutive eyes with idiopathic macular holes underwent vitrectomy with inner limiting membrane (ILM) peeling. Visual acuity testing, fundus-autofluorescence, and optical coherence tomography were performed at baseline, 1 week, 1 and 3 months after surgery. The fundus-autofluorescence images were obtained using Heidelberg Retina Angiograph 2 (Heidelberg Engineering, Heidelberg, Germany).
Stage 2, 3, and 4 macular holes were present in 4, 5, and 7 eyes, respectively. In all eyes, macular holes were successfully closed after surgery. All eyes showed marked hyperautofluorescence corresponding to the macular hole, and fluid cuff revealed mild hyperautofluorescence in 8 eyes. All stage 2 holes showed crescent-shaped hyperautofluorescence, and stage 3 holes showed round hyperautofluorescence with small disc-like hypoautofluorescence corresponding to preretinal pseudooperculum. At 1 week after surgery, the hyperautofluorescence completely disappeared in 14 eyes, while mild hyperautofluorescence remained in 2 eyes. At 1 month after surgery, although macular holes remained closed, obscure hyperautofluorescence recurred in 4 eyes. In 12 eyes, focal hypoautofluorescence was seen inside of areas of ILM peeling, and 7 eyes of them showed hypoautofluorescence along the retinal nerve fiber layer. However, all these abnormal findings spontaneously disappeared at 3 months.
Fundus-autofluorescence is noninvasive and might be useful in evaluating therapeutic success and retinal damage caused by retinal manipulation during surgery.
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