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A. M. Casella, G. Bressanin, J. A. Cardillo, A. P. Oguido, M. Malaguido; Chronic Central Serous Choriretinopathy and Helicobacter Pylori Infection. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4686.
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The objective of this case series is to report the treatment outcome of twelve patients diagnosed with chronic Central Serous Choriretinopathy (CSCR) invetigated for gastric Helicobacter pylori infection
Twelve patients diagnosed with CSCR for at least 6 months were submitted to further investigation on gastric infection for Helicobacter pylori by the urease test and gastric biopsy to confirm the diagnosis. The infected patients were treated with an association of clarithromycin (500mg, twice a day), amoxicillin (1g, twice a day) and lansoprazole (30mg, twice a day) for 10 days. The follow up examinations occurred between 3 months to 1.5 year.
Eleven out of 12 patients were positive for Helicobacter pylori infection. After two months a new gastric biopsy examination of the upper digestive tract confirmed the eradication of the bacteria in the treated group. All positive patients were followed monthly with visual acuity, OCT and Fluorescein Angiography. One patient was lasered after a negative gastric biopsy. One patient showed a significant improvement after treatment but the retinal detachment reappeared and laser procedure was necessary. Ten cases reported here showed improvement in visual acuity after treatment of infection with H. pylori as well as reported reduction of metamorphopsia and decreased serous detachment.
In spite of the encouraging results reported in this study, these findings need to be confirmed through large, multiple center case-control studies ruling out CSCR risk factors.
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