Purchase this article with an account.
J. J. Yunker, G. McGwin, Jr., R. W. Read; Impact of Statin Use on New-Onset Uveitis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4730. doi: https://doi.org/.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of statin use on subsequent uveitis development.
A case-control study was performed on patients from the Birmingham Veterans Affairs Medical Center (BVAMC) with a new diagnosis of uveitis occurring between 1997 and 2001, age-matched to non-uveitis controls. Patient data was reviewed for prior use of statin medications and selected systemic conditions. ICD-9 codes specific to uveitis were used to identify 92 incident cases of uveitis. These were matched 1:10 to control patients.Statistical analysis was performed to determine odds ratios for the incidence of uveitis between statin users and non-users, correlated with the duration of use of statin medications.
The use of statin medications was associated with a trend toward a 50% reduction in the risk of development of uveitis (OR 0.50, 95% CI 0.20-1.23). This association was present among both current (OR 0.46, 95% CI 0.15-1.46) and past (OR 0.54, 95% CI 0.18-1.67) statin users. Increasing duration of use was associated with greater reductions in risk, although not statistically significant.
The use of statin medications was associated with a 50% reduced risk of uveitis. Future clinical studies may provide direct evidence of the effectiveness of statins in lowering the incidence and complications of uveitis.
This PDF is available to Subscribers Only