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N. S. Ekdawi, J. D. Brewer, R. R. Torgerson, M. J. Camilleri, A. J. Bruce, R. S. Rogers, III, L. J. Maguire, K. H. Baratz; Lichen Planus and Cicatricial Conjunctivitis: Clinical Course and Response to Therapy in a Series of Eleven Patients. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4732.
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© ARVO (1962-2015); The Authors (2016-present)
To report the clinical features and therapy in patients with ocular involvement of lichen planus (LP).
We retrospectively reviewed the medical records of patients with LP who were seen at Mayo Clinic from 1976 to 2005 in order to identify all patients who had evidence of ocular involvement. Information was extracted from records regarding ocular involvement and therapy.
Eleven patients (2 male) with ocular involvement of LP were identified. Mean age of diagnosis was 57 (range 40-72) with an average of 4.1 years (range 0-21.2) from ocular symptom onset to diagnosis of ocular LP. All had bilateral eye involvement. Ocular findings included 10 patients with cicatricial conjunctivitis (conjunctival fibrosis, forniceal shortening, or caruncular scarring): of these 6 had symblepharon, 7 punctal stenosis, 4 keratitis (epithelial defects, scarring and pannus), 2 trichiasis, and 1 end stage cicatricial disease. One patient developed chronic conjunctivitis alone. Topical therapy with steroids (3), cyclosporine (5), or both (1) controlled symptoms in 4 patients. The remaining patients required systemic therapy for their ocular and/or systemic disease. One required silastic tubing for punctal stenosis.The systemic manifestations of lichen planus in our patients included 7 patients with genital involvement (6/10 female patients had vulvovaginal scarring, and 1 of 2 male had urethral stricture); 7 with oral involvement, 3 had otic involvement, 4 had skin involvement. In the 8 patients with multisystem disease, the ocular findings preceded LP at other sites in 2 patients
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