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J. Frucht-Pery, E. Eljarrat-Binstock1, F. Orucov, A. Solomon, O. Hamad, A. J. Domb; Charge Nanoparticles Delivery to the Eye Using Iontophoresis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4798. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate iontophoresis induced distribution of charged nanoparticles into ocular tissues.
Cathodal and anodal iontophoretic administrations were performed using polyacrylic hydrogels loaded with charged nanoparticle suspension (20 - 45 nm), applying a current intensity of 1.5 mA for five minute onto the cornea and sclera. At pre-set time points post treatment, eyes were dissected and tissues were evaluated for fluorescence intensity.
Strong fluorescence evidence was observed at anterior and posterior ocular tissues. Negative particle distribution profile revealed fast uptake into the outer ocular tissues [cornea ,conjunctiva,sclera] within 30 min post treatment, followed by particle migration into the inner tissues [retina and choroid] at 4 h. to 12 h. post treatment. The positively charged particles demonstrated better penetration abilities into retinal and choroidal tissues compared to the negatively charge particles.
This work provides an opening for the development of a new ocular therapeutic pathway using iontophoresis of extended release drug-loaded charged nanoparticles.
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