May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Charge Nanoparticles Delivery to the Eye Using Iontophoresis
Author Affiliations & Notes
  • J. Frucht-Pery
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • E. Eljarrat-Binstock1
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • F. Orucov
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • A. Solomon
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • O. Hamad
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • A. J. Domb
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • Footnotes
    Commercial Relationships  J. Frucht-Pery, Hadassit, P; E. Eljarrat-Binstock1, None; F. Orucov, None; A. Solomon, None; O. Hamad, None; A.J. Domb, Hadassit, P.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4798. doi:
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    • Get Citation

      J. Frucht-Pery, E. Eljarrat-Binstock1, F. Orucov, A. Solomon, O. Hamad, A. J. Domb; Charge Nanoparticles Delivery to the Eye Using Iontophoresis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4798.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate iontophoresis induced distribution of charged nanoparticles into ocular tissues.

Methods: : Cathodal and anodal iontophoretic administrations were performed using polyacrylic hydrogels loaded with charged nanoparticle suspension (20 - 45 nm), applying a current intensity of 1.5 mA for five minute onto the cornea and sclera. At pre-set time points post treatment, eyes were dissected and tissues were evaluated for fluorescence intensity.

Results: : Strong fluorescence evidence was observed at anterior and posterior ocular tissues. Negative particle distribution profile revealed fast uptake into the outer ocular tissues [cornea ,conjunctiva,sclera] within 30 min post treatment, followed by particle migration into the inner tissues [retina and choroid] at 4 h. to 12 h. post treatment. The positively charged particles demonstrated better penetration abilities into retinal and choroidal tissues compared to the negatively charge particles.

Conclusions: : This work provides an opening for the development of a new ocular therapeutic pathway using iontophoresis of extended release drug-loaded charged nanoparticles.

Keywords: retina • choroid • drug toxicity/drug effects 
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