May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Short-Term Corneal Endothelial Response to Wear of Silicone-Hydrogel Contact Lenses in Asian Eyes
Author Affiliations & Notes
  • M.-L. C. Coles-Brennan
    Brennan Consultants, Auburn Village, Australia
  • N. A. Brennan
    Brennan Consultants, Auburn Village, Australia
  • H. R. Connor
    Brennan Consultants, Auburn Village, Australia
  • R. G. McIlroy
    Brennan Consultants, Auburn Village, Australia
  • S. Gavras
    Brennan Consultants, Auburn Village, Australia
  • K. Moody
    Vistakon, Johnson & Johnson Vision Care, Inc, Jacksonville, Florida
  • T. Henderson
    Vistakon, Johnson & Johnson Vision Care, Inc, Jacksonville, Florida
  • Footnotes
    Commercial Relationships  M.C. Coles-Brennan, Vistakon, C; N.A. Brennan, Vistakon, C; H.R. Connor, Vistakon, C; R.G. McIlroy, Vistakon, C; S. Gavras, Vistakon, C; K. Moody, Vistakon, E; T. Henderson, Vistakon, E.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4865. doi:https://doi.org/
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      M.-L. C. Coles-Brennan, N. A. Brennan, H. R. Connor, R. G. McIlroy, S. Gavras, K. Moody, T. Henderson; Short-Term Corneal Endothelial Response to Wear of Silicone-Hydrogel Contact Lenses in Asian Eyes. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4865. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the role of silicone-hydrogel (Si-Hy) contact lens oxygen transmissibility (Dk/t) on the corneal endothelial bleb response in eyes of East Asian subjects.

Methods: : A total of 24 subjects of East Asian origin, attended for three separate sessions for a prospective, single-centre, trial. The following Si-Hy contact lenses were used: ACUVUE ® ADVANCETM with HYDRACLEARTM (Advance, -3D), ACUVUE ® OASYSTM with HYDRACLEARTM Plus (Oasys, -3D) and Focus® NIGHT & DAYTM (Night & Day, -3D). SofLens® 38 (+3D) was used as a positive hydrogel control. A modified Balaam’s crossover design was used to randomize presentation of sessions and contact lenses within sessions. Session one was a comparison between Oasys and SofLens 38 under closed eye conditions, session two was a comparison between Advance and Night & Day with eyes open and session three was a comparison between Oasys and Night & Day worn during eye closure. Corneal endothelial images were captured with the Topcon SP-3000P non-contact Specular Microscope after 20 minutes of wear and 5 and 10 minutes later after lens removal. Blebs were manually identified on these digital images by a masked observer. The area of blebs and total area under consideration were derived using IMAGEnetTM software and used to calculate percentage area of blebs. A boundary of equivalence of 1% was used as a clinically significant bleb area difference, and two-sided 95% confidence intervals were utilized to evaluate differences between lenses within each session.

Results: : In session 1, Soflens 38 produced a mean percentage area of blebs of 8.0% after 20 minutes, which was significantly different to that produced by Oasys (1.6%). In session 2, both Advance and Night & Day produced a mean percentage bleb area of 0.4%. In session 3, Oasys and Night & Day produced mean percentage bleb areas of 1.7% and 2.0%, respectively. The differences between Si-Hy lenses in sessions 2 and 3 were not statistically significant. Recovery from the bleb response was essentially complete in all cases except Soflens 38 within 10 minutes of lens removal.

Conclusions: : The similarity of bleb responses induced by the Si-Hy lenses under the tested wearing conditions is consistent with the proposition that increases in Dk/t above a certain level will produce minimal change in corneal physiological conditions.

Keywords: cornea: endothelium • contact lens 
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