May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Macular Spectral-Domain and Time-Domain Optical Coherence Tomography in Patients With X-Linked Retinoschisis
N. Z. Gregori; A. M. Berrocal; G. Gregori; T. G. Murray; R. W. Knighton; H. W. Flynn, Jr.; S. Dubovy; C. A. Puliafito; P. J. Rosenfeld
Author Affiliations & Notes
  • N. Z. Gregori
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • A. M. Berrocal
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • G. Gregori
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • T. G. Murray
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • R. W. Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • H. W. Flynn, Jr.
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • S. Dubovy
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • C. A. Puliafito
    Ophthalmology, University of Southern California, Los Angeles, California
  • P. J. Rosenfeld
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • Footnotes
    Commercial Relationships  N.Z. Gregori, None; A.M. Berrocal, None; G. Gregori, Carl Zeiss Meditec, F; University of Miami, P; T.G. Murray, None; R.W. Knighton, Carl Zeiss Meditec, F; University of Miami, P; H.W. Flynn, None; S. Dubovy, None; C.A. Puliafito, Carl Zeiss Meditec, F; Carl Zeiss Meditec, C; Carl Zeiss Meditec, R; P.J. Rosenfeld, Genentech, Alcon, Quark, Othera, Potentia, F; Genentech, Allergan, Quark, Othera, TargeGen, C; Genentech, Carl Zeiss Meditec, R.
  • Footnotes
    Support  Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4923. doi:
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      N. Z. Gregori, A. M. Berrocal, G. Gregori, T. G. Murray, R. W. Knighton, H. W. Flynn, Jr., S. Dubovy, C. A. Puliafito, P. J. Rosenfeld; Macular Spectral-Domain and Time-Domain Optical Coherence Tomography in Patients With X-Linked Retinoschisis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4923.

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Abstract

Purpose: : The purpose of this study is to evaluate macular anatomy in patients with X-linked retinoschisis (XLRS) using time-domain and higher-resolution spectral-domain OCT.

Methods: : Consecutive observational case series. Clinical features were obtained through retrospective chart review. Only eyes without prior surgical interventions were included. The OCT images were analyzed.

Results: : Twenty three eyes of 13 males with XLRS, age 3 months to 45 years, were identified. StratusOCT (n=13) and spectral-domain OCT (n=7) were available. On clinical examination, stellate spoke-like cystic maculopathy was present in 18 eyes, and an atrophic foveal lesion in 5 eyes. OCT revealed cystoid spaces accounting for retinal splitting in the inner nuclear layer in 20 eyes, both inner nuclear and outer nuclear layers in one eye, and outer plexiform layer in two eyes of one patient. A few small cysts, not accounting for the foveal splitting, were seen in the outer nuclear layer in 6 eyes and in the ganglion cell layer and/or nerve fiber layer in 10 eyes.

Keywords: retinal degenerations: hereditary • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • anatomy 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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