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K. Hirooka, M. Mizote, K. Fukuda, F. Shiraga; D-Allose Protects the Retina Against Ischemia Injury During Vitrectomy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4942.
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To investigate the protective effect of D-allose, a rare suger, on pressure induced ischemia during vitrectomy in the rabbit eye.
New Zealand White rabbits were divided into two groups: a D-allose group and a control group. In the D-allose group, intraocular irrigating solution contained D-allose. Rabbits underwent pars plana vitrectomy, and continuous intraocular irrigation at a perfusion pressure of 140 mm Hg were done for 45 minutes. Morphometric studies were performed to study the effect of D-allose on the histological changes induced by ischemia in the rabbit retina. Electroretinograms were taken before and after vitrectomy. Data were analyzed using an independent Student’s t-test.
Seven days after the ischemia, significant reductions in both the number of ganglion cells and the thickness of the inner plexiform layer were observed. D-allose significantly inhibited the ischemic injury of the inner retina (P < 0.05). On the seventh postoperative days, the recovery rate of b-wave amplitudes was significantly lower in a control group than that in a D-allose group (P < 0.05).
These results suggest that intraocular irrigation with D-allose during vitrectomy may protect the retina against ischemia-induced damage.
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