May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
D-Allose Protects the Retina Against Ischemia Injury During Vitrectomy
Author Affiliations & Notes
  • K. Hirooka
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • M. Mizote
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • K. Fukuda
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • F. Shiraga
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Footnotes
    Commercial Relationships  K. Hirooka, None; M. Mizote, None; K. Fukuda, None; F. Shiraga, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4942. doi:https://doi.org/
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    • Get Citation

      K. Hirooka, M. Mizote, K. Fukuda, F. Shiraga; D-Allose Protects the Retina Against Ischemia Injury During Vitrectomy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4942. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the protective effect of D-allose, a rare suger, on pressure induced ischemia during vitrectomy in the rabbit eye.

Methods: : New Zealand White rabbits were divided into two groups: a D-allose group and a control group. In the D-allose group, intraocular irrigating solution contained D-allose. Rabbits underwent pars plana vitrectomy, and continuous intraocular irrigation at a perfusion pressure of 140 mm Hg were done for 45 minutes. Morphometric studies were performed to study the effect of D-allose on the histological changes induced by ischemia in the rabbit retina. Electroretinograms were taken before and after vitrectomy. Data were analyzed using an independent Student’s t-test.

Results: : Seven days after the ischemia, significant reductions in both the number of ganglion cells and the thickness of the inner plexiform layer were observed. D-allose significantly inhibited the ischemic injury of the inner retina (P < 0.05). On the seventh postoperative days, the recovery rate of b-wave amplitudes was significantly lower in a control group than that in a D-allose group (P < 0.05).

Conclusions: : These results suggest that intraocular irrigation with D-allose during vitrectomy may protect the retina against ischemia-induced damage.

Keywords: neuroprotection • ischemia • retina 
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