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F. Zhang, Y. Li, Z. Tang, N. Nagai, C.-H. Heldin, X. Li; Neuroprotection of Vegf-b by Inhibition of Apoptosis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4945.
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the potential neuroprotective effect of VEGF-B.
real-time PCR analysis; the NMDA-induced retina injury model and the middle cerebral artery occlusion (MCAO)-induced brain ischemia model
Indeed, intravitreal (IV) administration of VEGF-B protein rescued the retinal neuronal cells from apoptosis in all the three neuronal layers in the retina. Moreover, VEGF-B protein treatment in the brain decreased stroke volume in the MCAO model, indicating that VEGF-B is a potent neuroprotective factor. Using real-time PCR analysis, we found that VEGF-B inhibits the expression of the BH3-only protein and other apoptotic/cell death-related genes in both the retinae and the brain.
Taken together, our data have shown that VEGF-B is a potent neuroprotective factor and may potentially offer a new therapeutic option for the treatment of ocular neurodegenerative diseases.
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